PMID: 18184470Jan 11, 2008Paper

Effect of preoperative biliary drainage on liver function changes in patients with malignant obstructive jaundice in the low bile duct before and after pancreaticoduodenectomy

Ai zheng = Aizheng = Chinese journal of cancer
Dong ChenJie-Fu Huang

Abstract

Pancreaticoduodenectomy can cause a high morbidity of postoperative complications. Preoperative biliary drainage can improve liver function. However, the effect of preoperative biliary drainage on preoperative liver function of the patients underwent pancreaticoduodenectomy for malignant obstructive jaundice in the low bile duct has seldom been reported. This study was to investigate the perioperative liver function changes and prognosis of the patients. Data of 98 patients, with total serum bilirubin level of over 85 mumol/L and underwent pancreaticoduodenectomy for malignant obstructive jaundice in the low bile duct, were collected. The correlation of liver function to serum bilirubin level, perioperative liver function changes, the impacts of preoperative biliary drainage and postoperative complications on postoperative liver function, and prognosis were investigated. The index of gamma-glutamyltransferase (GGT) was positively correlated to total bilirubin (TB) (r=0.368, P<0.001), but alkaline phosphatase (ALP) was not. Preoperative biliary drainage significantly reduced TB from (266+/-119) micromol/L to (184+/-115) micromol/L, DB from (160+/-75) micromol/L to (112+/-67) micromol/L, ALP from (161+/-88) U/L to (99+/-90) U/L, ...Continue Reading

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