Effect of preoperative cholangitis on prognosis of patients with hilar cholangiocarcinoma: A systematic review and meta-analysis

Medicine
Yudong WangXun Li

Abstract

The aim of this study was to compare the clinical outcomes between patients with preoperative cholangitis and noncholangitis patients to determine whether the preoperative cholangitis would be able to serve as an independent predictive factor on hilar cholangiocarcinoma (HCC) outcomes. A systematic literature search for reported preoperative cholangitis in patients with hilar cholangiocarcinoma was performed in 4 databases: PubMed, Web of Science, Embase, and the Cochrane Library, published from 1979 to 2017. In total, the initial search identified 1228 articles. Of these studies only 9 studies met the inclusion criteria and were included in this analysis. Differences between preoperative cholangitis existing and noncholangitis patients were observed in terms of mortality (RR = 2.29; 95% CI = 1.48-3.52; P = .0002), overall morbidity (RR = 1.15;95% CI = 1.00-1.32; P = .04), Liver failure (RR = 1.15;95% CI = 1.00-1.32; P = .04), Infection (RR = 1.52;95% CI = 1.16-2.00; P = .003), sepsis (RR = 2.40;95% CI = 1.25-4.5; P = .008). The results lend support to the notion that in hilar cholangiocarcinoma patients, the existence of preoperative cholangitis is statistically associated with the higher postoperative mortality and morbidity....Continue Reading

References

Jan 1, 1992·Annals of Surgery·H BismuthT Diamond
Oct 1, 1996·Annals of Surgery·A NakeebJ L Cameron
Mar 7, 2002·Current Treatment Options in Gastroenterology·Valerie Byrnes, Nezam Afdhal
Sep 1, 1957·A.M.A. Archives of Surgery·W A ALTEMEIERP I HOXWORTH
Jan 27, 2007·Journal of the American College of Surgeons·Olivier BatonDenis Castaing
Apr 28, 2007·World Journal of Gastroenterology : WJG·Yasuji Seyama, Masatoshi Makuuchi
Oct 13, 2009·Journal of Hepato-biliary-pancreatic Sciences·Satoshi HiranoRyosuke Kawasaki
Apr 6, 2011·Journal of the American College of Surgeons·Alan W HemmingRobin D Kim
Jun 10, 2011·Journal of Hepato-biliary-pancreatic Sciences·Hiroshi KawakamiMasahiro Asaka
Jul 17, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Min Soo ChoKyung Sik Kim
Sep 5, 2012·ANZ Journal of Surgery·Sun Choon SongMin Jung Kim
Jan 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Traian DumitrascuIrinel Popescu
May 21, 2014·Langenbeck's Archives of Surgery·Irinel Popescu, Traian Dumitrascu
May 30, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Katherine E PorukMatthew J Weiss
Jul 15, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Christopher E ForsmarkAndrew X Zhu

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Citations

Nov 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kota SaharaTimothy M Pawlik
Feb 5, 2021·Scientific Reports·Meng-Yu ZhangXian-Ming Xia
May 17, 2021·Journal of Hepato-biliary-pancreatic Sciences·Shinya NakamuraKazuaki Chayama

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