Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial

European Journal of Anaesthesiology
Uma SrivastavaSukhdev Mishra

Abstract

To evaluate the efficacy of a single preoperative dose of 600 mg of gabapentin for reducing postoperative pain and tramadol consumption after minilap open cholecystectomy. A total of 120 adult patients of either sex were randomly assigned to receive 600 mg of gabapentin or a matched placebo orally 2 h before operation in a double-blind manner. All the patients received gabapentin using the same technique. Postoperative analgesia was provided with intravenous patient-controlled analgesia with tramadol using a 50-mg initial bolus dose, 20-mg incremental dose, 15-min lockout interval and 4-h limit of 240 mg. Patients were assessed at 0, 2, 4, 8, 12, 24 and 48 h after operation for verbal analogue pain scores at rest and at movement. Consumption of tramadol on first and second postoperative days and any adverse effects were also recorded. Verbal analogue pain scores were significantly lower on first postoperative day at all times of observation both at rest and at movement in gabapentin group than in placebo group (P<0.01). Tramadol consumption was also reduced by 33% in gabapentin group. But pain scores and tramadol consumption were similar in two groups on second postoperative day. Sedation was common but the incidence of postope...Continue Reading

Associated Clinical Trials

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Citations

Jan 6, 2011·Neurologia Medico-chirurgica·Omur Kasimcan, Hulagu Kaptan
Mar 16, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Gaurav ChauhanNidhi Agrawal
Apr 6, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Felipe Melo CruzAuro del Giglio
Mar 29, 2014·Experimental Brain Research·Thomas Guttuso
Dec 3, 2014·International Immunopharmacology·Vlasta Orlić KarbićZlatko Trobonjača
May 22, 2010·Anesthesiology Clinics·Ofelia Loani Elvir-Lazo, Paul F White
Nov 28, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Theodoros PapathanasiouTrine Meldgaard Lund
Jan 17, 2013·The Journal of International Medical Research·M N DenizG Ugur
Oct 1, 2011·International Anesthesiology Clinics·Adam Young, Asokumar Buvanendran
Dec 12, 2018·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Juyi ZhangJuan Yang
Sep 18, 2010·Current Opinion in Anaesthesiology·Ofelia L Elvir-Lazo, Paul F White
Mar 19, 2016·Anesthesia and Analgesia·Michael C GrantChristopher L Wu
May 8, 2018·Pediatric Surgery International·Katherine J BaxterMehul V Raval
May 1, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Richard LennertzAngela Gibson

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