Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations

The Journal of Thoracic and Cardiovascular Surgery
J WesthuyzenS J Fleming

Abstract

Augmentation of antioxidant defenses may help protect tissues against ischemia-reperfusion injury associated with operations involving cardiopulmonary bypass. In this study we examined the effect of pretreating patients with alpha-tocopherol (vitamin E) and ascorbic acid (vitamin C) or placebo on injury to the myocardium. Seventy-six subjects undergoing elective coronary artery bypass grafting participated in a prospective, double-blind, placebo-controlled randomized trial, receiving either placebo or both 750 IU dl-alpha-tocopherol per day for 7 to 10 days and 1 gm ascorbic acid 12 hours before the operation. Plasma alpha-tocopherol concentrations, raised fourfold by supplementation, fell by 70% after the operation in the supplemented group and to negligible levels in the placebo group. There were no significant differences between the groups with respect to release of creatine kinase MB isoenzyme over 72 hours, nor in the reduction of the myocardial perfusion defect determined by thallium 201 uptake. Electrocardiography provided no evidence of a benefit from antioxidant supplementation. Thus the supplementation regimen prevented the depletion of the primary lipid soluble antioxidant in plasma, but provided no measurable reduc...Continue Reading

References

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Citations

Dec 5, 2003·Archives of Biochemistry and Biophysics·Nándor MarczinMagdi Yacoub
Sep 24, 2002·International Journal of Cardiology·Karol A KaminskiWlodzimierz J Musial
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David G RabkinHenry M Spotnitz
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Gerard P McGregor, Hans K Biesalski
Feb 28, 2008·Journal of Cardiovascular Medicine·Amedeo AnselmiAntonio Abbate
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·M A Wait, P A Grayburn
Nov 1, 2009·Expert Review of Clinical Pharmacology·Chengxue QinOwen L Woodman
Nov 24, 2005·Asian Cardiovascular & Thoracic Annals·Shahzad G Raja, Gilles D Dreyfus
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Michael S GoligorskyEdmond O'Riordan
Mar 13, 2009·Critical Reviews in Toxicology·Shirlee W TanKathryn R Mahaffey
Apr 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H AkarF Kolbakir
Nov 30, 2005·Atherosclerosis·A C KalioraH Schmidt

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