Abstract
Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days, and 18.5 days when TDD was applied preoperatively for 3 weeks, 6 weeks, and 9 weeks, respectively. Prolongation was significant after 6 weeks. Patency of the fistula was 93.5, 80.4, and 76.1% at respective weeks. Number of peripheral T-lymphocytes determined by a new monoclonal antibody diminished after 3 weeks. All animals were in normal health, requiring no special care for fluid, electrolyte, or protein replacement.
References
Jan 19, 1978·Nature·H LemkeK Rajewsky
Oct 1, 1979·Annals of Surgery·T E StarzlC G Halgrimson
Feb 1, 1976·Transplantation·C FrankssonO Ringdén
Aug 7, 1975·Nature·G Köhler, C Milstein
Feb 1, 1988·Transplantation·J J MysliwietzJ Maldacker
May 1, 1986·Transplantation·M M PrendergastK Tiver
Aug 1, 1986·Transplantation·E P Williamson, R A Sells
Sep 1, 1968·Annals of Surgery·J E MurrayJ H Harrison
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1974·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T KawaiR Benichoux
Jul 1, 1971·The Laryngoscope·J HarveyJ H Ogura
Apr 1, 1981·Transplantation·J L McKenzie, J W Fabre
Jun 1, 1982·Transplantation·J C WulffR Storb
Mar 1, 1981·Cellular Immunology·D G FischerH S Koren
Jan 1, 1981·Vox Sanguinis·Y ShibataN Ozawa
Apr 23, 1959·The Journal of Physiology·J L GOWANS
Jun 13, 1959·Nature·R SCHWARTZ, W DAMESHEK
Nov 16, 1963·Nature·M F WOODRUFF, N A ANDERSON
Apr 1, 1965·The Surgical Clinics of North America·W T NEWTON
Jun 1, 1960·The Journal of Clinical Investigation·R SCHWARTZ, W DAMESHEK
May 26, 1951·British Medical Journal·R E BILLINGHAMP B MEDAWAR
Jan 31, 1963·The Journal of Experimental Medicine·D D McGregor, J L Gowans