Effect of preoperative thoracic duct drainage on canine kidney transplantation

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Y FunakoshiT E Starzl

Abstract

Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days, and 18.5 days when TDD was applied preoperatively for 3 weeks, 6 weeks, and 9 weeks, respectively. Prolongation was significant after 6 weeks. Patency of the fistula was 93.5, 80.4, and 76.1% at respective weeks. Number of peripheral T-lymphocytes determined by a new monoclonal antibody diminished after 3 weeks. All animals were in normal health, requiring no special care for fluid, electrolyte, or protein replacement.

References

Oct 1, 1979·Annals of Surgery·T E StarzlC G Halgrimson
Feb 1, 1976·Transplantation·C FrankssonO Ringdén
Aug 1, 1986·Transplantation·E P Williamson, R A Sells
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1974·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T KawaiR Benichoux
Jul 1, 1971·The Laryngoscope·J HarveyJ H Ogura
Jun 1, 1982·Transplantation·J C WulffR Storb
Mar 1, 1981·Cellular Immunology·D G FischerH S Koren
Apr 23, 1959·The Journal of Physiology·J L GOWANS
Jun 13, 1959·Nature·R SCHWARTZ, W DAMESHEK
Apr 1, 1965·The Surgical Clinics of North America·W T NEWTON
Jun 1, 1960·The Journal of Clinical Investigation·R SCHWARTZ, W DAMESHEK
May 26, 1951·British Medical Journal·R E BILLINGHAMP B MEDAWAR
Jan 31, 1963·The Journal of Experimental Medicine·D D McGregor, J L Gowans

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Citations

Jan 5, 2002·Veterinary Surgery : VS·Andrew E KylesRandall E Morris

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