PMID: 3770657Sep 1, 1986Paper

Effect of preoptic region implants of dilute estradiol on the maternal behavior of ovariectomized, nulliparous rats

Hormones and Behavior
S E Fahrbach, D W Pfaff

Abstract

Estrogen implanted directly into the medial preoptic region of pregnant Charles River Sprague-Dawley rats hysterectomized and ovariectomized on Day 16 of gestation mimics the effects of systemic estrogen treatment at this time by reducing the latency to respond to foster pups with maternal behavior (Numan, Rosenblatt, and Komisaruk, 1977). The present report describes the pup-directed responses of ovariectomized, nulliparous Zivic-Miller Sprague-Dawley rats that received bilateral medial preoptic implants of either cholesterol (n = 11) or estradiol diluted 1:10 with cholesterol (n = 11). Two days after treatment these animals were housed with three foster pups: their responsivity to pups and quality of nests built were then assessed, at first hourly and then daily. Rats receiving intracranial estradiol required significantly shorter exposures to pups than did cholesterol-treated animals before initiating carrying and grouping of 3 dispersed pups in a maternal nest during a 15-min test. On other measures, however, the groups did not differ (e.g., proportion grouping pups overnight, time required to complete retrieval of pups to the nest, time required to rebuild a disrupted nest). Animals treated with cholesterol and animals wit...Continue Reading

References

Feb 1, 1977·Journal of Comparative and Physiological Psychology·M NumanB R Komisaruk
Apr 1, 1975·Physiology & Behavior·H I Siegel, J S Rosenblatt
Sep 1, 1975·Hormones and Behavior·H I Siegel, J S Rosenblatt
May 15, 1986·The Journal of Comparative Neurology·S E FahrbachD W Pfaff
Feb 15, 1985·Science·R S BridgesP C Doherty
Oct 1, 1974·Journal of Comparative and Physiological Psychology·M Numan
Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Nov 1, 1980·Physiology & Behavior·A S FlemingC Luebke

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Citations

Oct 23, 1995·Brain Research·M C Del CerroB R Komisaruk
Oct 1, 1995·Brain Research. Molecular Brain Research·C K Wagner, J I Morrell
Jan 1, 1988·Psychoneuroendocrinology·J S RosenblattA L Giordano
Jan 1, 1988·Psychoneuroendocrinology·M Numan
Jun 19, 2001·Psychoneuroendocrinology·R SlamberováI Vathy
Jun 6, 2003·Brain Research Bulletin·Terence V Sewards, Mark A Sewards
Sep 30, 2000·Journal of Neuroendocrinology·G González-MariscalJ S Rosenblatt
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·F ChampagneM J Meaney
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R S BridgesC E Lupini
Jun 1, 1994·Scandinavian Journal of Psychology·K Larsson
Mar 17, 2010·Endocrinology·Dara K ShahrokhMichael J Meaney
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ana C RibeiroDonald W Pfaff
May 8, 2013·Hormones and Behavior·Duangsuda ChokchaloemwongYupaporn Chaiseha
Oct 6, 2012·Journal of Women's Health·Laura M Glynn
Jan 1, 1989·New Directions for Child Development·J S Rosenblatt
Mar 3, 2004·Annals of the New York Academy of Sciences·M M McCarthyS K Amateau
Jan 10, 2013·Nature Communications·Hong-Xiang LiuHaruhiro Higashida
Feb 23, 2020·Histochemistry and Cell Biology·Takashi HashimotoKen-Ichi Matsuda
Jun 1, 1994·Acta Paediatrica. Supplement·R S Bridges
Apr 26, 2017·Annual Review of Neuroscience·Noga ZilkhaTali Kimchi
Jan 12, 2021·Development and Psychopathology·Elysia Poggi Davis, Angela J Narayan
May 22, 2019·Frontiers in Neuroendocrinology·Matthieu KellerThierry D Charlier
May 5, 2009·Neuroscience·S M Miller, J S Lonstein

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