Effect of preparation conditions on properties and permeability of chitosan-sodium hexametaphosphate capsules

Journal of Biomaterials Science. Polymer Edition
N Angelova, D Hunkeler

Abstract

Capsules were obtained by interpolymer complexation between chitosan (polycation) and sodium hexametaphosphate (SMP, oligoanion). The effect of the preparation conditions on the capsule characteristics was evaluated. Specifically, the influence of variables such as pH, ionic strength, reagent concentration, and additives on the capsule permeability properties was investigated using dextran as a model permeant. The capsule membrane permeability was found to increase by decreasing the chitosan/SMP ratio as well as adding mannitol to the oligoanion recipient bath. Increasing the ionic strength or the pH of the initial chitosan solution was also found to enhance the membrane permeability, moving the membrane exclusion limit to higher values. Generally, the capsules prepared tinder all tested conditions had a relatively low permeability which rarely exceeded a molecular cut-off of 40 kD based on dextran standards. Furthermore, the diffusion rate showed a strong temporal dependence, indicating that the capsules prepared under various conditions exhibit different apparent pore size densities on the surface. The results indicated that, in order to obtain the desired capsule mass-transfer properties, the preparation conditions should be...Continue Reading

References

Dec 12, 1997·Journal of Microencapsulation·H S Kaş
Jan 7, 1999·Drug Development and Industrial Pharmacy·O FeltR Gurny
Jul 23, 1999·Annals of the New York Academy of Sciences·A BartkowiakD Hunkeler
Jun 6, 2000·Advanced Drug Delivery Reviews·E Chornet, S Dumitriu
Jan 5, 1990·Biotechnology and Bioengineering·T YoshiokaM Kako

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Citations

Aug 15, 2002·International Journal of Pharmaceutics·N Angelova, D Hunkeler
Jun 15, 2011·Cellular & Molecular Immunology·Yi-Ling YeBor-Luen Chiang
Aug 29, 2007·International Journal of Nanomedicine·Jin-Oh YouChing-An Peng
Nov 20, 2012·Advanced Drug Delivery Reviews·Mei-Chin ChenHsing-Wen Sung
Sep 6, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Catarina M SilvaFrancisco Veiga
Jun 1, 2005·Journal of Biotechnology·Jian-Hang ZhuHanry Yu
Jun 5, 2019·Journal of Biomedical Materials Research. Part a·Ting LiJianhua Wang

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