Effect of pressure stress applied to the airway on cough-reflex sensitivity in Guinea pigs

American Journal of Respiratory and Critical Care Medicine
Johsuke HaraKazuo Kasahara

Abstract

We hypothesized that cough stress of the airway wall results in a self-perpetuating cough-reflex cycle in which antigen-induced increase in cough-reflex sensitivity results in pathologic cough, and the cough in turn further amplifies cough-reflex sensitivity. To examine cough-reflex sensitivity in an experimental animal model. We developed an experimental guinea pig model in which airway collapse similar to that in cough was induced by rapid negative pressure applied to the airway of artificially ventilated animals. We examined the influence of this stimulus on cough-reflex sensitivity to inhaled capsaicin and bronchoalveolar lavage (BAL) cell components. After the termination of artificial ventilation, the number of coughs due to capsaicin was measured, and BAL was performed. Capsaicin cough-reflex sensitivity and the number of BAL neutrophils were increased 6 hours after stimulus application, decreasing to control levels by 24 hours. Cough-reflex sensitivity or BAL cell components were not changed in the absence of stimulus application. The number of BAL neutrophils correlated significantly with the number of coughs. Hydroxyurea inhibited the stimulus-induced increase in the number of coughs and airway neutrophil accumulation...Continue Reading

References

Jan 1, 1992·The American Review of Respiratory Disease·K KuboJ H Newman
Sep 1, 1991·British Journal of Industrial Medicine·T GordonD Sheppard
Jul 1, 1990·The American Review of Respiratory Disease·P G VentrescaK F Chung
Oct 1, 1989·Journal of Applied Physiology·D J DusserJ A Nadel
Jul 1, 1988·British Journal of Clinical Pharmacology·L E AyalaR W Fuller
Jun 1, 1988·Journal of Applied Physiology·D B JacobyJ A Nadel
Aug 1, 1984·The American Review of Respiratory Disease·P M O'ByrneM J Holtzman
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A I Pack, R G DeLaney
Feb 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·O F PedersenS Lyager
Jul 1, 1995·The European Respiratory Journal·J G Widdicombe
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M FujimuraT Matsuda
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Jun 1, 1997·Thorax·I D PavordF E Hargreave
Oct 1, 1996·Pulmonary Pharmacology·K SekizawaH Sasaki
Nov 6, 1998·Journal of Applied Physiology·A XiangS Hasegawa
Aug 27, 1999·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·M M PizzichiniF E Hargreave
Nov 24, 1999·The Journal of Physiology·M A McAlexanderB J Undem
Jun 3, 2000·The European Respiratory Journal·M M PizzichiniF E Hargreave
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·H D HeldS Uhlig
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q LiuM Yasui
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·J D RicardG Saumon
Aug 16, 2001·Respiration Physiology·C Y HoL Y Lee
Dec 12, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S MyouS Nakao
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Séverine Oudin, Jérôme Pugin
Nov 2, 2002·British Journal of Pharmacology·Yanlin JiaJohn A Hey
Jul 19, 2003·American Journal of Respiratory and Critical Care Medicine·Lina H K Lim, Elizabeth M Wagner
Jul 25, 2003·The Japanese Journal of Physiology·Naoki HayamaKenji Eguchi
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Rekha ChaudhuriNeil C Thomson
Aug 31, 2004·Journal of Cellular Physiology·Terence M O'ConnorFergus Shanahan
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·David A GronebergK Fan Chung
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Akio NiimiKian Fan Chung
Jan 6, 2007·Journal of Applied Physiology·Elizabeth M Wagner, John Jenkins

❮ Previous
Next ❯

Citations

Feb 16, 2012·Journal of Veterinary Internal Medicine·M K SinghR E Pollard
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Helen SumnerJaclyn A Smith
May 26, 2009·Respiratory Research·Shaoping XieKian Fan Chung
Apr 26, 2015·The Kaohsiung Journal of Medical Sciences·Li YuZhongmin Qiu
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Dec 24, 2010·The Veterinary Journal·Katerina K Adamama-MoraitouTimoleon S Rallis
Jan 13, 2009·Pediatric Clinics of North America·Anne B Chang
Jun 19, 2013·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Mar 27, 2019·Journal of Veterinary Internal Medicine·Lynelle R Johnson, William Vernau
Apr 2, 2020·Physiological Research·M LucanskaR Pecova
Mar 31, 2021·Respiratory Physiology & Neurobiology·Jana PlevkovaTomas Buday

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.