PMID: 36937May 1, 1979

Effect of presynaptic neurotoxins from the bee and cobra venoms on spontaneous mediator secretion from the motor nerve endings in mice

Biulleten' eksperimental'noĭ biologii i meditsiny
M N KamenskaiaA I Miroshnikov


Phospholipases A2 (PhLA) from the bee and cobra venoms induced the three-phasic changes in miniature end-plate potential (MEPP) frequency recorded in the mouse diaphragm muscle: an initial fall of transmitter release followed by a transient increase before the final complete blockade. The removal of Ca2+ from the perfusing solution (below 10(-9) M) prevented the presynaptic effect of both PhLA. If all PhLA molecules were washed out by the Ca-free solution, the subsequent exposure to a standard solution (2 mM Ca2+) action provoked an increase in MEPP frequency. The agents capable of increasing the axoplasmic Ca concentration (ions K+, hypertonic sucrose and uncoupler--TTFB) caused the usual increase of MEPP frequency in the muscles treated with PhLA. Apparently, the presynaptic biockade induced by PhLA cannot be due to the depletion of transmitter stores.


Nov 12, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T AbeR Miledi
Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·B R DasGupta, H Sugiyama
Apr 1, 1974·Acta Physiologica Scandinavica·M A Kamenskaya, S Thesleff
Dec 1, 1965·The Journal of Physiology·D Elmqvist, D S Feldman
May 8, 1965·Nature·P W Gage, D M Quastel

Related Concepts

Muscle - Striated (Skeletal) - Diaphragm (Mmhcc)
Process of Secretion
Culture Techniques
Cobra Venoms
Mediator of activation protein
Cell Secretion

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