PMID: 11321381Apr 26, 2001Paper

Effect of preterm formula with and without long-chain polyunsaturated fatty acids on the urinary excretion of F2-isoprostanes and 8-epi-prostaglandin F2alpha

Journal of Pediatric Gastroenterology and Nutrition
C StierA Leonhardt

Abstract

The objective of this study was to evaluate the effect of conventional and long-chain polyunsaturated fatty acids (LCP)-enriched preterm formula on the endogenous formation of F2-isoprostanes and 8-epi-prostaglandin (PG) F2alpha as possible markers of lipid peroxidation in preterm infants during their first weeks of life. In a prospective, randomized, double-blind study, infants received either formula enriched with LCP (n = 8), standard preterm formula (n = 7), or (expressed) breast milk (n = 8). Urine was sampled at study entry and after the study period of 3 weeks. The formation of F2-isoprostanes and 8-epi-PGF2alpha was evaluated by measuring the urinary excretion by gas chromatography-mass spectrometry. No differences in the urinary excretion of F2-isoprostanes and 8-epi-PGF2alpha were observed at the end of the study period. This result suggests that supplementation of a preterm formula with LCP for a period of 3 weeks does not stimulate lipid peroxidation in preterm infants.

References

Sep 1, 1992·The American Journal of Physiology·R D Smith, A L Goldin
Jan 1, 1991·Free Radical Biology & Medicine·J D Morrow, L J Roberts
Jul 15, 1993·European Journal of Biochemistry·H Sies
Jul 1, 1994·Acta Paediatrica·E VarsilaS Andersson
Jan 1, 1994·European Journal of Pediatrics·G A Russell
Sep 1, 1993·Pediatric Research·C V SmithS J Elliott
Mar 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·T E InderB J Taylor
Mar 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·A LucasS M Gore
Jan 3, 1994·Biochimica Et Biophysica Acta·J D MorrowL J Roberts
Jan 1, 1993·Journal of Applied Physiology·K H KangM Banerjee
May 1, 1993·The American Journal of Clinical Nutrition·B Halliwell, S Chirico
May 1, 1993·The American Journal of Clinical Nutrition·H Esterbauer
Jul 1, 1996·Circulation·M ReillyG A FitzGerald
Apr 1, 1997·Biochimica Et Biophysica Acta·L J Roberts, J D Morrow
Apr 2, 1999·Pediatrics·J P Guignard, A Drukker

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Citations

May 8, 2004·Free Radical Research·Anne E BardenSusan L Prescott
Mar 17, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·S D ReuterC J Fernandes

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