PMID: 9438531Jan 23, 1998Paper

Effect of pretreatment with alcohol on subsequent endocrine and immune responses in the adult male rat

Alcoholism, Clinical and Experimental Research
C Rivier

Abstract

We have previously shown that daily injection of alcohol for 3 days induced a significant and long-lasting blunting of the hypothalamic-pituitary-adrenal (HPA) axis response to a subsequent treatment with this drug. The fact that, in contrast, the HPA axis response to footshocks was not altered by prior alcohol administration, suggested the presence of a phenomenon of selective neuroendocrine tolerance. To further test this hypothesis, we determined whether an initial alcohol challenge would alter the ACTH response to immune signals, such as interleukin-1beta (IL-1beta) and/or endotoxin (lipopolysaccharide; LPS). Because of the functional connection between the HPA axis and immune responses, we also determined whether the LPS-induced release of tumor necrosis factor-alpha and interleukin-6, as well as IgG and IgM responses to an antigenic challenge, would be influenced by previous exposure to alcohol. We show here that the intragastric injection of 3 g of alcohol/kg daily for 3 days did not significantly alter the ability of IL-1beta (400 ng/kg) or LPS (1 microg/kg), both injected intravenously 7 days later, to release ACTH. Drug pretreatment did not significantly alter the tumor necrosis factor-alpha response to the low dose o...Continue Reading

References

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Dec 1, 1996·Alcoholism, Clinical and Experimental Research·G ZeldinA M Diehl

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Citations

Jan 26, 2006·Alcoholism, Clinical and Experimental Research·Angela DolganiucGyongyi Szabo
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·D D RasmussenC W Wilkinson
Sep 17, 2004·Biochemical and Biophysical Research Communications·John J Haddad
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Soon Lee, Catherine Rivier
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Peter RosenbergerClaudia D Spies

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