Effect of Previous-Year Vaccination on the Efficacy, Immunogenicity, and Safety of High-Dose Inactivated Influenza Vaccine in Older Adults

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Carlos A DiazGranadosDavid P Greenberg

Abstract

High-dose inactivated influenza vaccine (IIV-HD) is an alternative to the standard-dose inactivated influenza vaccine (IIV-SD) in the United States for influenza prevention in older adults. IIV-HD improved efficacy relative to IIV-SD in a randomized controlled trial. Recent observational studies suggest that previous influenza vaccination may influence the immunogenicity and effectiveness of current-season vaccination. The original study was a double-blind, randomized trial comparing IIV-HD to IIV-SD in adults aged ≥65 years over 2 influenza seasons. A subset of year 1 (Y1) participants reenrolled in year 2 (Y2), receiving vaccine by random assignment in both years. We evaluated the effect of Y1 vaccination on Y2 relative vaccine efficacy (VE), immunogenicity (hemagglutination inhibition [HAI] titers), and safety among reenrolled participants. Of 14 500 Y1 participants, 7643 reenrolled in Y2. Relative to participants who received IIV-SD both seasons, VE was higher for IIV-HD vaccinees in Y2 (28.3% overall; 25.1% for Y1 IIV-HD, Y2 IIV-HD; and 31.6% for Y1 IIV-SD, Y2 IIV-HD). In multivariate logistic regression models, Y1 vaccine was not a significant modifier of Y2 VE (P= .43), whereas Y2 IIV-HD remained significantly associated...Continue Reading

Associated Clinical Trials

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Citations

Aug 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Danuta M SkowronskiGaston De Serres
Aug 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlos A DiazGranadosDavid P Greenberg
Nov 5, 2016·Expert Review of Vaccines·Corwin A RobertsonDavid P Greenberg
Nov 30, 2018·Influenza and Other Respiratory Viruses·Caroline Quinn PrattEvan J Anderson
Jan 29, 2019·Expert Review of Vaccines·Sandrine I SamsonRosalind Hollingsworth
Mar 23, 2017·The Journal of Infectious Diseases·Arnold S Monto
Aug 6, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anne M ButlerLeah J McGrath
May 11, 2020·The Journal of Allergy and Clinical Immunology·Claire E GustafsonJörg J Goronzy

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