PMID: 1211466Sep 1, 1975Paper

Effect of primary bile acids on bile lipid secretion from perfused dog liver

The American Journal of Physiology
N E HoffmanA F Hosmann

Abstract

An isolated canine liver perfusion technique featuring a second dog as the pump oxygenator was used to compare biliary lipid secretion during randomized, steady-state perfusions at two different rates of cholyl taurine or chenodeoxycholyl taurine infusions. The hepatic extraction of the trihydroxy-conjugated bile acid was considerably greater than that of the dihydroxy conjugate, possibly explained by ultrafiltration experiments which indicated that cholyl taurine was less protein bound than chenodeoxycholyl taurine. Both bile acids induced phospholipid and cholesterol secretion that was linearly proportional to bile acid secretion. However, each mole of secreted chenodeoxycholyl taurine induced a greater relative secretion of phospholipid and cholesterol than did that of cholyl taurine. Thus in the canine liver, the two primary bile acids are extracted at different rates and induce biliary secretion of different relative lipid composition.

Citations

May 1, 1978·The American Journal of Digestive Diseases·N F LaRussoA E Cowen
Mar 1, 1982·Klinische Wochenschrift·K SchmidtJ Schmitt
Nov 28, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cindy KunneRonald P J Oude Elferink
Feb 1, 1979·European Journal of Clinical Investigation·R E PouponS Erlinger
Jul 30, 1976·European Journal of Clinical Investigation·R PouponS Erlinger
Jan 1, 1978·Gut·M Ponz De LeonR H Dowling
Jun 1, 1991·European Journal of Clinical Investigation·A Lanzini, T C Northfield
Mar 1, 1984·The Japanese Journal of Surgery·Y IshikawaT Akiyoshi
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F O NerviB O Ronco
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SakisakaK Tanikawa
Jun 1, 1978·The American Journal of Physiology·N E HoffmanR A Smallwood
Aug 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·F GuertinB Tuchweber
Nov 1, 1996·The British Veterinary Journal·J I FernándezM Mañas Almendros
Aug 1, 1979·Japanese Journal of Pharmacology·K UchidaN Takeuchi

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