Abstract
The primary tumor side is emerging as a major prognostic factor for patients with metastatic colorectal cancer (mCRC). We examined the survival data from 2 randomized studies to determine whether the outcomes differ between patients with mCRC with right-sided primary (RSP) tumors and those with left-sided primary (LSP) tumors after selective internal radiation therapy (SIRT) plus mFOLFOX6 (folinic acid [leucovorin], 5-fluorouracil, oxaliplatin) chemotherapy, versus chemotherapy alone. Separate and combined analyses were performed on the data from the SIRFLOX and FOXFIRE global trials, which compared chemotherapy plus SIRT with chemotherapy alone for patients with mCRC liver metastases. The primary tumor side data were prospectively collected. The principal outcome measure was overall survival (OS) stratified by treatment and primary tumor side. In the combined analysis of all 739 patients enrolled, SIRT had no effect on OS (median OS, 24.3 vs. 24.6 months; hazard ratio [HR], 1.021; P = .810). For the 179 patients (24.2%) with a RSP tumor, OS was improved with the addition of SIRT (median, 22.0 vs. 17.1 months HR, 0.641; P = .008). The addition of SIRT was not associated with a significant difference in OS among the 540 patients...Continue Reading
Citations
Feb 15, 2019·Asia-Pacific Journal of Clinical Oncology·Shehara MendisPeter Gibbs
Jul 18, 2019·Cardiovascular and Interventional Radiology·Nancy KemenyConstantinos T Sofocleous
Feb 14, 2019·Asia-Pacific Journal of Clinical Oncology·Matthew BurgeChristos S Karapetis
May 30, 2020·Abdominal Radiology·Yanqiao RenBin Xiong
Jul 25, 2020·The British Journal of Radiology·Thomas Helmberger
Sep 23, 2020·EJNMMI Research·Caren van RoekelMarnix G E H Lam
Dec 17, 2019·International Journal of Cancer. Journal International Du Cancer·Jane WolstenholmeRicky A Sharma
Dec 18, 2020·Seminars in Interventional Radiology·Patrick D Sutphin, Suvranu Ganguli
Nov 18, 2020·World Journal of Clinical Oncology·Jack MartinEmmanuel Huguet
Dec 2, 2020·Clinical Colorectal Cancer·P KaranicolasUNKNOWN Gastrointestinal Disease Site Group
Apr 4, 2021·Cancers·Justin Kwan, Uei Pua
Nov 7, 2020·Journal of Cancer Research and Clinical Oncology·Max MasthoffMoritz Wildgruber
Aug 28, 2021·Journal of Clinical Medicine·Matthias Philipp FabritiusMichael Ingrisch
Feb 18, 2021·AJR. American Journal of Roentgenology·Vincent WuSuvranu Ganguli
Sep 21, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary F MulcahyUNKNOWN EPOCH Investigators
Nov 7, 2021·Deutsche medizinische Wochenschrift·Thomas J EttrichThomas Seufferlein
Dec 23, 2020·The Journal of Thoracic and Cardiovascular Surgery·Harvey I Pass