Effect of prior eccentric contractions on lactate/H+ transport in rat skeletal muscle

The American Journal of Physiology
H Pilegaard, S Asp

Abstract

The effect of prior eccentric contractions on skeletal muscle lactate/H+ transport was investigated in rats. Lactate transport was measured in sarcolemmal giant vesicles obtained from soleus and red (RG) and white gastrocnemii (WG) muscles 2 days after intense eccentric contractions (ECC) and from the corresponding contralateral control (CON) muscles. The physiochemical buffer capacity was determined in the three muscle types from both ECC and CON legs. Furthermore, the effect of prior eccentric contractions on release and muscle content of lactate and H+ during and after supramaximal stimulation was examined using the perfused rat hindlimb preparation. The lactate transport rate was lower (P < 0.05) in vesicles obtained from ECC-WG (29%) and ECC-RG (13%) than in vesicles from the CON muscles. The physiochemical buffer capacity was reduced (P < 0.05) in ECC-WG (13%) and ECC-RG (9%) compared with the corresponding CON muscles. There were only marginal effects on the soleus muscle. Muscle lactate concentrations and release of lactate during recovery from intense isometric contractions were lower (P < 0.05) in ECC than in CON hindlimbs, indicating decreased anaerobic glycogenolysis. In conclusion, the sarcolemmal lactate/H+ transp...Continue Reading

References

Jun 1, 1991·Journal of Applied Physiology·R L LieberJ Fridén
May 31, 1991·Biochimica Et Biophysica Acta·C Juel
Jun 1, 1990·Archives of Biochemistry and Biophysics·D A Roth, G A Brooks
Jul 1, 1987·Journal of Applied Physiology·K P O'ReillyW J Evans
Mar 1, 1985·The American Journal of Physiology·L L SprietN L Jones
Nov 1, 1984·The American Journal of Anatomy·R B Armstrong, R O Phelps
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R B ArmstrongJ A Schwane
Jun 1, 1983·Muscle & Nerve·D J NewhamR H Edwards
Dec 1, 1981·Pflügers Archiv : European journal of physiology·C T Davies, M J White
Apr 15, 1994·The Biochemical Journal·F Wibrand, C Juel
Jan 1, 1994·Physiological Reviews·R H Fitts
Mar 1, 1993·Acta Physiologica Scandinavica·J C McDermott, A Bonen
Oct 1, 1995·Journal of Applied Physiology·D A LoweR B Armstrong
Oct 1, 1995·Journal of Applied Physiology·S AspE A Richter
Mar 9, 1996·Molecular and Cellular Biochemistry·K J McCullaghA Bonen
May 1, 1997·The American Journal of Physiology·S KristiansenE A Richter

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Citations

Feb 26, 2008·Journal of Strength and Conditioning Research·W Jackson DavisW Bart Davis
May 6, 2009·Pflügers Archiv : European journal of physiology·David BishopKnut Schneiker
Sep 16, 2016·Journal of Physical Therapy Science·Wonder Passoni HiginoJosé Alexandre C A Leme

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