Effect of prior ethanol experience on dopamine overflow in accumbens of AA and ANA rats

European Journal of Pharmacology
M NurmiK Kiianmaa

Abstract

The purpose of this study was to investigate the effect of repeated ethanol administration on dopamine overflow in the nucleus accumbens of alcohol-preferring AA (Alko Alcohol) and alcohol-avoiding ANA (Alko Nonalcohol) rats. Dopamine is a possible mediator of the reinforcing effects of ethanol, but it has previously been shown that ethanol-naïve alcohol-preferring AA and alcohol-nonpreferring ANA rats do not differ in their dopaminergic reaction to an intraperitoneal ethanol injection (0.5-2.0 g/kg), as assessed by measuring extracellular dopamine in the nucleus accumbens with in vivo microdialysis. Here a group of AA rats drank 10% (v/v) ethanol voluntarily-continual access for 5-15 days, limited access for 3 weeks-while a yoked group of AA rats and a yoked group of ANA rats received the same amount intragastrically by intubation. The rats were implanted with guide cannulas on the fourth week of limited access. Dopamine overflow was monitored in the microdialysis perfusate after 1 g/kg i.p. ethanol. The AA and the ANA rats that received ethanol non-contingently showed the same dopaminergic response to this as naïve animals have before. The group that had ingested the ethanol voluntarily showed, however, a significantly smalle...Continue Reading

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Citations

Sep 15, 2001·Brain Research. Developmental Brain Research·R M PhilpotC L Kirstein
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S Cowen, A J Lawrence
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·M NurmiK Kiianmaa
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·M S Cowen, A J Lawrence
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·P J ConrodS Mankowski
Jan 3, 2013·Alcoholism, Clinical and Experimental Research·Margaret BroadwaterLinda P Spear
Feb 27, 2003·Alcoholism, Clinical and Experimental Research·Kalervo KiianmaaAndrey E Ryabinin
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erkki Tupala, Jari Tiihonen
Nov 15, 2001·Alcoholism, Clinical and Experimental Research·M KoistinenK Kiianmaa

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