PMID: 9423838Jan 10, 1998Paper

Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge

Infection and Immunity
Michael S DonnenbergM M Levine

Abstract

Two studies of adult volunteers were performed to determine whether prior enteropathogenic Escherichia coli (EPEC) infection confers protective immunity against rechallenge. In the first study, a naive control group and volunteers who had previously ingested an O55:H6 strain were fed an O127:H6 strain. In the second study, a control group and volunteers who had previously ingested either the O127:H6 strain or an isogenic eae deletion mutant of that strain were challenged with the homologous wild-type strain. There was no significant effect of prior infection on the incidence of diarrhea in either study. However, in the homologous-rechallenge study, disease was significantly milder in the group previously challenged with the wild-type strain. Disease severity was inversely correlated with the level of prechallenge serum immunoglobulin G against the O127 lipopolysaccharide. These studies indicate that prior EPEC infection can reduce disease severity upon homologous challenge. Further studies may require the development of new model systems.

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Citations

Oct 14, 2000·Annual Review of Cell and Developmental Biology·D L GoosneyB B Finlay
Feb 26, 2005·Infection and Immunity·Jan-Michael A KlapprothIfor R Williams
Mar 24, 2012·Future Microbiology·Jennifer A KalilJoanne M Langley
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·W-G SonV P J Gannon
Oct 5, 2013·Clinical Microbiology Reviews·Matthew A CroxenB Brett Finlay
Jul 17, 2010·Digestive Diseases and Sciences·Alicia Hsin-Ming ChangJulie Parsonnet
Jun 6, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Cristiane Barros CarbonareMagda Maria Sales Carneiro-Sampaio
Jul 6, 2000·Journal of Clinical Microbiology·A Parissi-CrivelliJ A Girón
Jan 1, 2006·EcoSal Plus·Odilia L C Wijburg, Richard A Strugnell
Jun 27, 2006·BMC Veterinary Research·Tim StakenborgJohan Peeters

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