PMID: 6984034Nov 1, 1982Paper

Effect of prior hyperthermia on subsequent thermal enhancement of radiation damage in mouse intestine

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
J C Marigold, S P Hume

Abstract

Hyperthermia given in conjunction with X-rays results in a greater level of radiation injury than following X-rays alone, giving a thermal enhancement ratio (TER). The effect of prior hyperthermia ('priming') on TER was studied in the small intestine of mouse by giving 42 X 0 degrees C for 1 hour at various times before the combined heat and X-ray treatments. Radiation damage was assessed by measuring crypt survival 4 days after radiation. TER was reduced when 'priming' hyperthermia was given 24-48 hours before the combined treatments. The reduction in effectiveness of the second heat treatment corresponded to a reduction in hyperthermal temperature of approximately 0 X 5 degrees C, a value similar to that previously reported for induced resistance to heat given alone ('thermotolerance') (Hume and Marigold 1980). However, the time courses for development and decay of the TER response were much longer than those for 'thermotolerance', suggesting that different mechanisms are involved in thermal damage following heat alone and thermal enhancement of radiation damage.

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Citations

Sep 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J C Marigold, S P Hume
Feb 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D H SchamhartR Van Wijk
Jan 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J HavemanJ Wondergem
Sep 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Wondergem, J Haveman
Aug 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Wondergem, J Haveman

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