Effect of probiotic Saccharomyces boulardii in experimental giardiasis

Beneficial Microbes
M R S RibeiroMaria A Gomes

Abstract

The aim of the study was to assess the efficacy of Saccharomyces boulardii in experimental treatment of giardiasis and its impact on intestinal integrity and some functions of gerbils infected with Giardia lamblia. 28 gerbils (Meriones unguiculatus), aged 4-6 weeks, were divided into four groups: untreated and uninfected control (CT); infected with G. lamblia (IGL); treated with S. boulardii (SB); and infected with G. lamblia and treated with S. boulardii (ITSB). The SB and ITSB groups received S. boulardii 15 days prior to being infected with G. lamblia. The treatment continued until completion of the experiment (22nd day). The IGL and ITSB groups were gavage-inoculated with G. lamblia ensuring one-week infection. 4 h before euthanasia, all animals were gavaged with a solution containing diethylenetriamine-pentaacetic acid (DTPA) marked with technetium-99mTc DTPA to determine intestinal permeability. The small intestine was removed for histopathological, morphometric analysis and count of trophozoites adhered to the mucosa. The selected probiotic caused an approximate reduction of 70% of parasite load, which was determined by attached trophozoites (P<0.01) and immune-marked trophozoites (P<0.05). Treatment with S. boulardii (S...Continue Reading

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Citations

Dec 9, 2020·Journal of Applied Microbiology·Mayana Rodrigues S RibeiroMaria Aparecida Gomes
Jan 30, 2021·Frontiers in Microbiology·Elena FeketeAndre G Buret
Jul 30, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Nasrin Dashti, Mitra Zarebavani

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