Effect of probiotics on obesity-related markers per enterotype: a double-blind, placebo-controlled, randomized clinical trial.

The EPMA Journal
Eun-Ji SongYoung-Do Nam

Abstract

Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype. Fifty subjects with body mass index over 25 kg/m2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis. Gut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, v...Continue Reading

References

Jan 1, 1983·Annual Review of Microbiology·G D Shockman, J F Barrett
Dec 1, 1995·Obesity Research·Y MatsuzawaK Kotani
Dec 1, 1995·Current Opinion in Immunology·B Charlton, K J Lafferty
Aug 5, 2000·Allergy·G MazzarellaG F Abbate
Mar 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S P BorrielloV Valtonen
Feb 27, 2004·The American Journal of Clinical Nutrition·Ian JanssenRobert Ross
Dec 2, 2004·Expert Opinion on Biological Therapy·Ronald B MossDennis J Carlo
Dec 14, 2004·Journal of Applied Physiology·Christian K Roberts, R James Barnard
Jun 10, 2006·The American Journal of Clinical Nutrition·Robert J BoyleMimi L K Tang
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 2, 2007·Critical Pathways in Cardiology·Jean-Pierre Després
Sep 28, 2007·Letters in Applied Microbiology·M C ColladoS Salminen
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 3, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P MastromarinoC Midulla
Dec 20, 2008·Current Opinion in Rheumatology·Ananthila AnandacoomarasamyLyn March
Jun 6, 2009·The Journal of Physiology·Peter J Turnbaugh, Jeffrey I Gordon
Sep 16, 2009·Annals of Nutrition & Metabolism·Claudio Galli, Philip C Calder
Apr 7, 2010·Science Translational Medicine·Peter J TurnbaughJeffrey I Gordon
Jun 19, 2010·Experimental Biology and Medicine·Naoki TakemuraKei Sonoyama
Sep 17, 2010·Science Translational Medicine·Andrew P FeinbergM Daniele Fallin
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
Jun 28, 2011·Bioinformatics·Robert C EdgarRob Knight
Sep 3, 2011·Science·Gary D WuJames D Lewis
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Nov 22, 2012·Gut and Liver·Alexander R MoschenHerbert Tilg
Apr 6, 2013·Korean journal of family medicine·Seung-Pil JungJong-Yeon Kim
Jul 3, 2013·Immunobiology·Victoria R RichardsonAngela M Carter
Jul 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan M Han, Megan K Levings
Oct 22, 2013·Bioinformatics·Jiajie ZhangAlexandros Stamatakis
Dec 7, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Doaa Mohammed YoussefEman Mohamed Elbehidy

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Citations

Aug 6, 2020·High-throughput·Eric Banan-Mwine DaliriDeog-Hwan Oh
Apr 26, 2021·Trends in Microbiology·Bo-Min LvHong-Yu Zhang

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Datasets Mentioned

BETA
DRA008223

Software Mentioned

Progenesis QI
Random Allocation
SIMCA
Trimmomatic
SPSS
PEAR
CAN
Pro
NMDS
USEARCH

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