PMID: 522903Nov 1, 1979Paper

Effect of procainamide on transmembrane action potentials in guinea-pig papillary muscles as affected by external potassium concentration

Naunyn-Schmiedeberg's Archives of Pharmacology
H SadaT Ban

Abstract

Effects of procainamide (PA), 0.18, 0.37 and 0.74 mmol/l, on the transmembrane potential were studied in isolated guinea-pig papillary muscles, superfused with modified Tyrode's solution (external K concentration, [K]0 = 5.4 mmol/l) at the basic driving rate of 1 Hz. PA, at 0.37 mmol/l, significantly reduced the maximum rate of rise of action potential (Vmax) with no change in the resting potential. When 2.7 mmol/l [K]0 of the superfusate was exchanged for 15 mmol/l [K]0 solution a decrease in Vmax induced by 0.37 mmol/l PA became more prominent with decrease in resting potential. The reduction of Vmax at steady state was less at lower driving rates (0.25 and 0.5 Hz) and more at higher driving rates (2-5 Hz) than at 1 Hz in 2.7, 5.4 and 10.0 mmol/l [K]0 solution. Such changes were enhanced concentration-dependently by PA at 5.4 mmol/l [K]0. Also, the changes became more significant with an increase in [K]0 from 2.7 mmol/l to 5.4 mmol/l and then to 10.0 mmol/l. The recovery process of Vmax proceeded with two components. The time course of the slow component seen in the Vmax of the first response after interruption of basic driving stimulation at 1 Hz, followed an approximate monoexponential function. The time constants were 6.3,...Continue Reading

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Citations

Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·A VarròD A Lathrop
Oct 1, 1983·Computers and Biomedical Research, an International Journal·T Ban
Nov 1, 1980·Journal of Molecular and Cellular Cardiology·K R Courtney
Aug 24, 2011·IEEE Transactions on Bio-medical Engineering·Kwanghyun SohnBonnie B Punske
Oct 1, 1983·American Heart Journal·M R Rosen, A L Wit
Aug 1, 1988·British Journal of Pharmacology·S IkeguchiC Kawai
Oct 1, 1984·Circulation Research·A O GrantH C Strauss
May 31, 2003·Canadian Journal of Physiology and Pharmacology·François HélieRené Cardinal
Nov 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·M Aomine

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