PMID: 3766575Sep 1, 1986Paper

Effect of procaine on the pH of buffered and unbuffered cardioplegic solutions

American Journal of Hospital Pharmacy
S P LoucasB Mehl

Abstract

Changes in pH values were studied in two types of cardioplegic admixtures containing procaine 0.95 meq/L: an institutional formulation based on Ringer's injection and buffered with tromethamine injection 3.6%, and Plegisol (Abbott Laboratories) buffered with sodium bicarbonate injection 8.4%. Initial pH was measured in the buffered and unbuffered solutions before the addition of procaine and after the addition of 13 mL of procaine hydrochloride injection 2% or 260 mg of procaine hydrochloride powder (reference standard). Buffered 1-L admixtures containing procaine hydrochloride injection were stored (the institutional formulations in glass and the Plegisol admixtures in flexible plastic bags) at 3-5 degrees C or 25 degrees C. Plegisol admixtures were prepared with 10 mL (10 meq or 840 mg) of buffer as directed by the manufacturer or with 3 mL (3 meq) of buffer. Admixture pH was tested after various time intervals. Of the unbuffered solutions containing procaine, pH values were lower in Plegisol than in the institutional formulation. Of the procaine-containing buffered Plegisol solutions, only the admixture containing 3.0 mL of buffer and procaine prepared from powder had an initial pH in the acceptable range of 7.30-7.60. In al...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Hospital Pharmacy
Y W CheungK P Flora
American Journal of Hospital Pharmacy
J H BeijnenW J Underberg
© 2021 Meta ULC. All rights reserved