PMID: 7021744Aug 1, 1981Paper

Effect of progesterone on lipid metabolism in the intact rat

The Journal of Endocrinology
D ShirlingJ D Baird

Abstract

Females rats implanted with progesterone gained weight more rapidly than control animals and had an increased proportion of total body fat. Restriction of food intake to control levels demonstrated that the weight changes was not dependent on increased energy intake. Serum concentrations of cholesterol, phospholipid and non-esterified fatty acid were raised in hormone-treated rats but triglyceride levels were normal. Endogenous production of triglyceride was also unchanged. Total postheparin lipoprotein lipase activity was increased in the plasma of progesterone-treated rats largely due to increased release of the extrahepatic protamine sulphate-labile fraction. The basal rate of lipogenesis was also increased in adipocytes isolated from hormone-treated rats as was the insulin-stimulated rate of oxidation of[1-14 C]glucose. Basal and adrenaline-stimulated rates of fat cell lipolysis were, however, unchanged by treatment with progesterone.

Citations

Dec 17, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Kapil Dev MehtaKrishna K Sharma
May 13, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Eva MillesiManfred Walzl
Oct 20, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Ewa Stelmanska, Julian Swierczynski
Aug 28, 2012·Molecular and Cellular Endocrinology·Isabel R SchlaepferBritta M Jacobsen
May 29, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Ewa StelmanskaJulian Swierczynski
Nov 6, 2008·Molecular and Cellular Endocrinology·Yonghua ZhangAndré Tchernof
Jul 1, 2008·Animal Reproduction Science·Anna StraussEva Millesi
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·André TchernofVan Luu-The
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·S Rodriguez-CuencaP Roca
Nov 1, 1982·The American Journal of Physiology·J M Gray, M R Greenwood
Jun 3, 2021·International Journal of Molecular Sciences·Agata Wawrzkiewicz-JałowieckaGraça Soveral
Jun 1, 1997·Metabolism: Clinical and Experimental·M T Sutter-Dub, P Cordoba
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Wilnoska Wilnellia D'silvaAshwini Patil

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