Effect of progesterone on the metabolism of noradrenaline in rabbit uterine endometrium and myometrium

Naunyn-Schmiedeberg's Archives of Pharmacology
J A Kennedy, I S de la Lande

Abstract

The metabolism of (-)-3H-noradrenaline was examined in the endometrium and the myometrium from rabbits which had received 17 beta-oestradiol, either alone (oestrogen-dominated) or with progesterone (progesterone-dominated). The progesterone treatment resulted in a 2.5-fold increase in 3H-NMN formation in the endometrium, with no change in 3H-DOPEG, 3H-DOMA or 3H-OMDA formation. In the myometrium, progesterone caused a 5-fold increase in 3H-NMN formation and a 2.5-fold increase in 3H-OMDA formation, but did not affect 3H-DOPEG or 3H-DOMA formation. In the progesterone-dominated endometrium, both 3H-NMN and 3H-OMDA formation were strongly inhibited by cocaine 30 mumol/l. When O-methylation was inhibited by a COMT inhibitor, cocaine prevented the resultant increases in deamination of noradrenaline to 3H-DOPEG and in the accumulation of 3H-noradrenaline by the tissue. The 3H-noradrenaline which accumulated in endometria, in which both MAO and COMT were inhibited, was firmly bound; desipramine 3 mumol/l and (+)-amphetamine 10 mumol/l were equieffective with cocaine 30 mumol/l in inhibiting the accumulation. Cocaine 30 mumol/l was without effect on 3H-NMN and 3H-OMDA formation in the progesterone-dominated myometrium, nor did it prev...Continue Reading

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Citations

Oct 1, 1989·Journal of Steroid Biochemistry·L J Spicer, J M Hammond
Nov 7, 2008·Human Reproduction Update·Stefan R HanssonBertil Casslén
Aug 1, 1988·Clinical and Experimental Pharmacology & Physiology·D A Parker, I S de la Lande
Jan 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·D A ParkerI Parker
Aug 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·V MarinoS Wing
Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·J A Kennedy, I S de la Lande
Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·V MarinoD A Parker
Jan 1, 1994·Archives of Oral Biology·D A ParkerI Parker

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