Effect of prolonged antibiotic treatment on cognition in patients with Lyme borreliosis

Neurology
Anneleen BerendeBart J Kullberg

Abstract

To investigate whether longer-term antibiotic treatment improves cognitive performance in patients with persistent symptoms attributed to Lyme borreliosis. Data were collected during the Persistent Lyme Empiric Antibiotic Study Europe (PLEASE) trial, a randomized, placebo-controlled study. Study participants passed performance-validity testing (measure for detecting suboptimal effort) and had persistent symptoms attributed to Lyme borreliosis. All patients received a 2-week open-label regimen of intravenous ceftriaxone before the 12-week blinded oral regimen (doxycycline, clarithromycin/hydroxychloroquine, or placebo). Cognitive performance was assessed at baseline and after 14, 26, and 40 weeks with neuropsychological tests covering the cognitive domains of episodic memory, attention/working memory, verbal fluency, speed of information processing, and executive function. Baseline characteristics of patients enrolled (n = 239) were comparable in all treatment groups. After 14 weeks, performance on none of the cognitive domains differed significantly between the treatment arms (p = 0.49-0.82). At follow-up, no additional treatment effect (p = 0.35-0.98) or difference between groups (p = 0.37-0.93) was found at any time point. Pa...Continue Reading

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Citations

Mar 7, 2020·Current Opinion in Rheumatology·Robert T Schoen
May 28, 2020·BMJ : British Medical Journal·Bart Jan KullbergJoppe W Hovius
Oct 9, 2019·BMC Infectious Diseases·Anneleen BerendeRoy P C Kessels
Jul 2, 2019·Médecine et maladies infectieuses·X GockoUNKNOWN endorsed by the following scientific societies
Mar 13, 2021·Current Opinion in Neurology·Rick Dersch, Ameeta E Singh
Jun 2, 2021·Deutsche medizinische Wochenschrift·Rick Dersch, Volker Fingerle

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Clinical Trials Mentioned

NCT01207739

Software Mentioned

PLEASE
SPSS

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