Abstract
To investigate whether longer-term antibiotic treatment improves cognitive performance in patients with persistent symptoms attributed to Lyme borreliosis. Data were collected during the Persistent Lyme Empiric Antibiotic Study Europe (PLEASE) trial, a randomized, placebo-controlled study. Study participants passed performance-validity testing (measure for detecting suboptimal effort) and had persistent symptoms attributed to Lyme borreliosis. All patients received a 2-week open-label regimen of intravenous ceftriaxone before the 12-week blinded oral regimen (doxycycline, clarithromycin/hydroxychloroquine, or placebo). Cognitive performance was assessed at baseline and after 14, 26, and 40 weeks with neuropsychological tests covering the cognitive domains of episodic memory, attention/working memory, verbal fluency, speed of information processing, and executive function. Baseline characteristics of patients enrolled (n = 239) were comparable in all treatment groups. After 14 weeks, performance on none of the cognitive domains differed significantly between the treatment arms (p = 0.49-0.82). At follow-up, no additional treatment effect (p = 0.35-0.98) or difference between groups (p = 0.37-0.93) was found at any time point. Pa...Continue Reading
References
Nov 1, 1991·Archives of Neurology·L B KruppJ J Halperin
Nov 22, 1990·The New England Journal of Medicine·E L LogigianA C Steere
Jan 1, 1988·Annals of the New York Academy of Sciences·J J HalperinR J Dattwyler
Feb 1, 1982·The British Journal of Clinical Psychology·D E BroadbentK R Parkes
Oct 15, 1994·Annals of Internal Medicine·N A ShadickM H Liang
Nov 1, 1996·Infection·H EiffertH J Christen
Feb 1, 1997·Journal of Clinical and Experimental Neuropsychology·S SchagenJ Lindeboom
Nov 18, 1997·Archives of Neurology·E A GaudinoL B Krupp
Apr 1, 1998·Medical Care·S J CoonsR D Hays
Jan 19, 1999·Journal of Clinical and Experimental Neuropsychology·J HochstenbachH Schoonderwaldt
Nov 30, 1999·Applied Neuropsychology·W V AdamsJ D Klein
Jul 9, 1999·The Journal of Infectious Diseases·E L LogigianA C Steere
Jul 14, 2001·The New England Journal of Medicine·M S KlempnerA Weinstein
Nov 14, 2002·Neuropsychology Review·Holly James Westervelt, Robert J McCaffrey
Jun 25, 2003·Neurology·R F KaplanM S Klempner
Jan 26, 2006·Journal of the International Neuropsychological Society : JINS·John G KeilpBrian A Fallon
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary P WormserRobert B Nadelman
Oct 12, 2007·Neurology·B A FallonH A Sackeim
Jul 26, 2008·Annual Review of Psychology·John W Graham
Nov 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A MyglandUNKNOWN European Federation of Neurological Societies
Oct 18, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R EikelandG C Løhaugen
Feb 2, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·John N AucottKathleen B Kortte
Aug 1, 2014·Expert Review of Anti-infective Therapy·Daniel J CameronElizabeth L Maloney
Oct 17, 2014·BMC Infectious Diseases·Anneleen BerendeBart Kullberg
Aug 11, 2015·Epilepsy & Behavior : E&B·Rachel GaliotoGeoffrey Tremont
Mar 31, 2016·The New England Journal of Medicine·Anneleen BerendeBart Jan Kullberg
Sep 2, 2016·Epilepsy Currents·Adriana Bermeo-Ovalle
Nov 5, 2016·Frontiers in Psychology·Nathalie R de VentHilde M Huizenga
Mar 8, 2017·PloS One·Joost A Agelink van RentergemHilde M Huizenga
Citations
May 22, 2019·Journal of Child Neurology·Donald L Gilbert
Mar 7, 2020·Current Opinion in Rheumatology·Robert T Schoen
May 28, 2020·BMJ : British Medical Journal·Bart Jan KullbergJoppe W Hovius
Oct 9, 2019·BMC Infectious Diseases·Anneleen BerendeRoy P C Kessels
Sep 29, 2019·JAMA Neurology·Virgilio Hernández RuizKarine Pérès
Jul 2, 2019·Médecine et maladies infectieuses·X GockoUNKNOWN endorsed by the following scientific societies
Mar 13, 2021·Current Opinion in Neurology·Rick Dersch, Ameeta E Singh
Jun 2, 2021·Deutsche medizinische Wochenschrift·Rick Dersch, Volker Fingerle