Effect of prolonged physical exercise on the fibrinolytic system

European Journal of Applied Physiology and Occupational Physiology
L RöckerH U Altenkirch

Abstract

The effect of a test marathon race on plasma fibrinolytic activity (FA) was studied in 16 endurance athletes before, immediately after, 3 h, and 31 h after the run. Tissue plasminogen activator (t-PA) activity increased about 31-fold immediately after the run. Similar increases were found in t-PA antigen concentration. Plasminogen activator inhibitor (PAI) was not detectable immediately after the race and was significantly decreased 3 h (P less than 0.05) and 31 h (P less than 0.01) later. B beta 15-42 peptide increased by 0.63 pmol.ml-1 (P less than 0.001), D-dimer by 68.3 ng.ml-1 (P less than 0.05). Euglobulin lysis time (ELT) was reduced from 109 to 18 min (P less than 0.001). The increased t-PA activity and t-PA antigen concentration disappeared in the course of the first 3 h after exertion. ELT also reached its pre-exercise levels at this time. Thirty-one hours after the race ELT and t-PA antigen levels were slightly but significantly reduced (P less than 0.05), whereas B beta 15-42 peptide remained increased (P less than 0.05). t-PA activity was unchanged compared with pre-exercise values. It seems that the exercise-induced FA is mainly caused by the marked increase of t-PA antigen and t-PA activity.

References

Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D CollenJ Vermylen
Dec 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E W FergusonL L Bernier
Mar 1, 1976·Journal of Applied Physiology·G L DavisM Britton
Sep 15, 1985·Thrombosis Research·D Langleben, L A Moroz
Jun 1, 1986·Journal of Applied Physiology·M AndrewG Heigenhauser
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·L RöckerB Heyduck
Apr 1, 1970·British Journal of Haematology·J D CashA G Allan
Nov 1, 1974·The American Journal of Physiology·J E Karp, W R Bell
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B WimanM Rånby
May 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T M HyersJ J Franks
Dec 1, 1984·Journal of the American College of Cardiology·K L ChanR J Chambers
Mar 1, 1963·Journal of Applied Physiology·S G IATRIDIS, J H FERGUSON
Aug 1, 1951·The Journal of Clinical Investigation·M B STRAUSSE C ROSSMEISL

❮ Previous
Next ❯

Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·A B MolzL Röcker
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·N Takashima, T Higashi
Nov 29, 2007·European Journal of Applied Physiology·Leif-Hendrik BoldtHanns-Christian Gunga
Aug 27, 2013·European Journal of Applied Physiology·Brian R KupchakJeff S Volek
Jun 23, 2004·Preventive Medicine·Tetsuo OhkuwaYoshihiko Yamazaki
Feb 20, 2003·Thrombosis Research·Markus LinsRüdiger Simon
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Günther SumannWolfgang Schobersberger
Sep 30, 2003·British Journal of Sports Medicine·J E Smith
Feb 28, 2004·Sports Medicine·Mahmoud S El-SayedSajad Ahmadizad
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·J A De PazJ González-Gallego
Oct 1, 1994·Thrombosis Research·A TakadaT Urano
May 1, 1992·Progress in Cardiovascular Diseases·J FareedR Pifarre
Jul 28, 2015·The Physician and Sportsmedicine·Amanda L ZaleskiBeth A Taylor
Jul 18, 2006·Journal of Science and Medicine in Sport·J RibeiroJ Duarte
Sep 6, 2005·Thrombosis Research·Giuseppe LippiFederico Schena
Jan 22, 2015·European Journal of Applied Physiology·Brian R KupchakLawrence E Armstrong
Apr 8, 2017·Scandinavian Journal of Medicine & Science in Sports·E L StepienW Drygas
Nov 17, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Selda KahramanFatih Demirkan
Aug 22, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Christoph SuckerStefan Möhlenkamp
Jul 15, 2017·The Physician and Sportsmedicine·Amanda L ZaleskiCraig Denegar
Jan 11, 2018·European Journal of Sport Science·Emma Kate ZadowMurray John Adams
Jul 26, 2017·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Beth A TaylorPaul D Thompson
Oct 30, 2004·Medicine and Science in Sports and Exercise·Jamie A CooperChristopher J Womack
Jun 10, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M S El-Sayed, W Nieuwenhuizen
Mar 2, 2011·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Beth ParkerPaul Thompson
Apr 3, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zlatko FrasWayne L Chandler
Mar 21, 1998·Medicine and Science in Sports and Exercise·C WeissP Bärtsch
May 5, 2000·Medicine and Science in Sports and Exercise·M S El-SayedM Chester
Feb 29, 2000·Medicine and Science in Sports and Exercise·M N SawkaA J Young
Oct 1, 2020·International Journal of Molecular Sciences·Fasih Ahmad Rahman, Matthew Paul Krause
May 8, 2000·Journal of Applied Physiology·P J van den BurgI A Huisveld
Jun 9, 2016·The Journal of Nutrition, Health & Aging·T NickelM Halle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.