PMID: 9551054Apr 29, 1998Paper

Effect of prolonged pulsatile shear stress in vitro on endothelial cell seeded PTFE and compliant polyurethane vascular grafts

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
A GiudiceandreaGeorge Hamilton

Abstract

Compliance mismatch between graft and native artery, and failure of the graft to develop an endothelial lining are the two main factors in graft failure. The objective of this study was to assess a new compliant graft for effective cell attachment and cell retention at physiological levels of pulsatile shear stress over a 6-hour period of physiological pulsatile flow. Laboratory haemodynamic study. Human umbilical vein endothelial cells labelled with 111In-oxine were seeded on compliant polyurethane (CPU) and polytetrafluoroethylene (PTFE) vascular grafts. These were then exposed to varying shear stresses of up to 13.8 +/- 0.6 dyn/cm2 using a pulsatile flow model. Dynamic scintigraphy images were acquired using a gamma camera linked to an on-line computer during 6 h of perfusion and data presented as mean +/- standard error of mean. Mean seeding efficiencies were significantly different at 4,316 +/- 505 and 825 +/- 504 CPM/cm2 on the CPU and PTFE grafts, respectively (p = 0.018). The flow experiment showed a higher percentage of cells retained on the CPU graft after exposure to shear stress caused by pulsatile flow compared to PTFE with respect to time. After 6 h pulsatile perfusion there was a significantly higher proportion o...Continue Reading

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Citations

Apr 5, 2001·Journal of Biomedical Materials Research·A M SeifalianG Hamilton
May 15, 2002·Journal of Biomedical Materials Research·Henryk SalacinskiAlexander M Seifalian
Jan 24, 2002·Medical & Biological Engineering & Computing·H J SalacinskiA M Seifalian
Jan 22, 2003·Microvascular Research·Alok TiwariAlexander M Seifalian
Nov 19, 2003·Clinics in Plastic Surgery·Rachael H SchmedlenJennifer L West
Jun 5, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Alok TiwariGeorge Hamilton
Nov 25, 2000·The British Journal of Surgery·N R TaiA M Seifalian
Feb 28, 2006·Tissue Engineering·Philippe FernandezLaurence Bordenave
Nov 28, 2013·Journal of Materials Science. Materials in Medicine·Amaliris RuizKristyn S Masters
Mar 29, 2011·Annals of Vascular Surgery·Mital DesaiAlexander M Seifalian
Mar 19, 2013·Journal of Biomedical Materials Research. Part a·Amaliris RuizKristyn S Masters
Sep 9, 2004·The Journal of Thoracic and Cardiovascular Surgery·Helmut GulbinsBruno Reichart
Oct 19, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H J SalacinskiA M Seifalian
Mar 4, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S SarkarA M Seifalian
Dec 21, 2005·Pathologie-biologie·Dina S VaraAlexander M Seifalian
Feb 7, 2012·Vascular and Endovascular Surgery·Mark TattertonShervanthi Homer-Vanniasinkam
Mar 23, 2001·Journal of Biomaterials Applications·H J SalacinskiR J Carson
Sep 21, 2004·Cell Proliferation·S T RashidA M Seifalian
Feb 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Michel R HoenigJulie H Campbell
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alok TiwariAlexander M Seifalian
Jan 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S T RashidA M Seifalian
Jun 26, 2012·Journal of Tissue Engineering and Regenerative Medicine·F BoccafoschiM Cannas
Dec 18, 2001·Journal of Biomedical Materials Research·Henryk J SalacinskiAlexander M Seifalian

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