Effect of prolonged treatment with adrenergic neuron blocking drugs on sympathoadrenal reactivity in rats

European Journal of Pharmacology
H GrobeckerI J Kopin

Abstract

The effects of repeated high doses of the adrenergic neuron blocking drug guanethidine or a hexahydropyrazinoindole compound (2-guanyl-1,2,3,10,10a, hexahydro-1,2,a-pyrazinoindole, EMD 21192) (30 mg/kg i.p., 21.5 mg/kg i.p. respectively, equimolar doses) on sympathoadrenal activity were investigated in normotensive adult rats. During treatment for 5 weeks with either guanethidine or EMD 21192 the systemic blood pressure fell steadily. Noradrenaline content in the heart and vas deferens were decreased markedly by guanethidine and to a much less degree by EMD 21192. EMD 21192 markedly lowers the catecholamine content of the adrenal medulla, presumably as a result of inhibition of dopamine-beta-hydroxylase. The plasma catecholamine concentrations reflected the different sites of action of the drugs in the sympathoadrenal system, i.e. guanethidine mainly reduced circulating norepinephrine and dopamine-beta-hydroxylase by more than 50%, whereas EMD 21192 decreased considerably by the total catecholamines (mainly epinephrine) without altering significantly in the plasma norepinephrine. Disappearance or reduction of fluorescent nerve endings in the iris and the heart and a decrease of the intensity of fluorescence in chromaffin cells ...Continue Reading

References

Feb 1, 1975·Life Sciences·D P HenryR H Williams
May 1, 1971·The Journal of Pharmacy and Pharmacology·L MaîtreH Brunner
Jan 1, 1972·British Journal of Pharmacology·B A BerkowitzJ H Tarver
Aug 1, 1974·Journal of Neurochemistry·M Fillenz, D P West
Oct 1, 1974·European Journal of Pharmacology·S R O'Donnell, N Saar
Mar 1, 1971·Circulation Research·R Weinshilboum, J Axelrod
Apr 28, 1971·Nature: New Biology·R WeinshilboumI J Kopin
Nov 1, 1971·The Histochemical Journal·O Eränkö, L Eränkö
Jan 1, 1971·European Journal of Pharmacology·G BurnstockM L Mashford
Sep 3, 1971·Science·R Weinshilboum, J Axelrod
Jan 1, 1965·Annual Review of Pharmacology·A L BOURA, A F GREEN

Citations

Dec 24, 2004·Neurotoxicity Research·D M Jacobowitz
Nov 1, 1989·Journal of the Autonomic Nervous System·B A Barron, G R Van Loon
Jan 1, 1984·Microbiology and Immunology·J SakuraiK Endo
Oct 19, 2014·Circulation Research·Elizabeth S BarrieWolfgang Sadee
Nov 24, 1999·The American Journal of Physiology·L C NavegantesI C Kettelhut

Related Concepts

Adrenal Glands
Metazoa
Diastolic Blood Pressure
Catecholamines
Dopamine-beta-monooxygenase
Guanethidine Sulfate (2: 1), 14C-Labeled
Indoles
Myocardium
Neurons
Norepinephrine, (+, -)-Isomer

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