Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy

World Journal of Gastroenterology : WJG
Gwang Ha KimIl-Kwun Chung

Abstract

To investigate the efficacy of premedication with pronase, a proteolytic enzyme, in improving image quality during magnifying endoscopy. The study was of a blinded, randomized, prospective design. Patients were assigned to groups administered oral premedication of either pronase and simethicone (Group A) or simethicone alone (Group B). First, the gastric mucosal visibility grade (1-4) was determined during conventional endoscopy, and then a magnifying endoscopic examination was conducted. The quality of images obtained by magnifying endoscopy at the stomach and the esophagus was scored from 1 to 3, with a lower score indicating better visibility. The endoscopist used water flushes as needed to obtain satisfactory magnifying endoscopic views. The main study outcomes were the visibility scores during magnifying endoscopy and the number of water flushes. A total of 144 patients were enrolled, and data from 143 patients (M:F=90:53, mean age 57.5 years) were analyzed. The visibility score was significantly higher in the stomach following premedication with pronase (73% with a score of 1 in Group A vs 49% in Group B, P<0.05), but there was no difference in the esophagus visibility scores (67% with a score of 1 in Group A vs 58% in Gr...Continue Reading

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Citations

Apr 11, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenshi YaoHisao Tajiri
Feb 18, 2020·World Journal of Gastroenterology : WJG·Jun-Liang TehJimmy Bok-Yan So
Jul 19, 2018·World Journal of Gastroenterology : WJG·Hey-Long ChingMark E McAlindon
Feb 21, 2021·Gastroenterología y hepatología·Glòria Fernández-EsparrachUNKNOWN en representación de la Asociación Española de Gastroenterología, la Sociedad Española de Endoscopia Digestiva y la Sociedad

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