PMID: 9423996Jan 10, 1998Paper

Effect of proparacaine on tropicamide-induced mydriasis

Optometry and Vision Science : Official Publication of the American Academy of Optometry
John SiderovJ Y Wong

Abstract

The use of a topical anesthetic before the instillation of a mydriatic is recommended in order to enhance both the rate and magnitude of pupillary dilation. However, there is a paucity of data supporting the prior use of topical anesthetics with tropicamide, the most commonly used mydriatic agent in optometric practice. Therefore, we conducted a study to determine the clinical effect of proparacaine on tropicamide-induced pupillary dilation. We investigated the effects of prior instillation of 0.5% proparacaine (Ophthetic) on pupillary dilation with 0.5% tropicamide (Mydriacyl) using a double-blind, placebo-controlled protocol on two groups of young adult subjects. Thirty subjects, aged between 18 and 30 years, were divided into 2 groups of 15, based on whether they had light- or dark-colored irides. The pupils of both eyes of each subject were dilated with tropicamide, but only one eye, chosen at random, received proparacaine (experimental condition), whereas the other was administered a saline placebo (control condition). Pupil diameter was measured using a ruler and magnifying loupe. Subjects with light-colored irides had a greater average pupil dilation than subjects with dark-colored irides. There was a small, statisticall...Continue Reading

Citations

Nov 16, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anders Behndig
Dec 26, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Heather A AndersonKaren D Fern
Dec 15, 2016·Seminars in Ophthalmology·Brijesh TakkarRashmi Ramachandran
May 2, 2007·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·David E HaddadDavid M Krumholz
Dec 1, 2005·Optometry and Vision Science : Official Publication of the American Academy of Optometry·John Siderov, Sarah Nurse
Mar 10, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Junsang ChoSusan M Culican

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