Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes

The British Journal of Nutrition
C DemignéC Rémésy

Abstract

In the present study the actual role of propionic acid in the control of fatty acid and cholesterol synthesis was investigated in isolated liver cells from fed rats maintained in the presence of near-physiological concentrations of glucose, glutamine and acetate. Using 3H2O for lipid labelling, propionate appears as an effective inhibitor of fatty acid synthesis and to a lesser extent of cholesterol synthesis, even at the lowest concentration used (0.6 mmol/l). Butyrate is a potent activator of both synthetic pathways, and the activating effect was not counteracted by propionate. Using 1-[14C]acetate, it was observed that propionate at a moderate concentration, or 1 mmol oleate/l, are both very effective inhibitors of 14C incorporation into fatty acid and cholesterol. This incorporation was drastically inhibited when propionate and oleate were present together in the incubation medium. The net utilization of acetate by rat hepatocytes was impaired by propionate, in contrast to oleate. 1-[14C]butyrate was utilized at a high rate for fatty acid synthesis, but to a lesser extent for cholesterol synthesis; both processes were unaffected by propionate. Intracellular citrate concentration was not markedly depressed by propionate, whe...Continue Reading

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Citations

Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Catherine NicolleChristian Rémésy
Apr 16, 2005·Current Opinion in Biotechnology·Arthur C OuwehandNina Rautonen
May 10, 2005·The British Journal of Nutrition·Michel Beylot
Feb 18, 2011·Critical Reviews in Food Science and Nutrition·Willem F BroekaertJan A Delcour
May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Oct 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henrike M HamerKristin Verbeke
Apr 15, 2010·Pakistan Journal of Biological Sciences : PJBS·A M Ezz El-Arab
Mar 8, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E C AguilarJ I Alvarez-Leite
Oct 16, 2014·Food & Nutrition Research·Yadong Zhong, Margareta Nyman
Jun 1, 2010·Journal of Food Science and Technology·Arun Kumar Verma, Rituparna Banerjee
Nov 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa de Jesus De-PaulaOrestes Vicente Forlenza
Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartosz FotschkiZenon Zduńczyk
Jan 25, 2011·Appetite·Tulika AroraGary Frost
Aug 10, 2010·Biochimica Et Biophysica Acta·Sa'ad H Al-LahhamKoen Venema
Jul 6, 2012·Molecular Nutrition & Food Research·Kristina E Andersson, Per Hellstrand
Mar 22, 2016·International Journal of Molecular Sciences·Xuyun HeHoukai Li
Apr 15, 2008·Critical Reviews in Food Science and Nutrition·Cristina Martínez-VillaluengaConcepción Vidal-Valverde
Aug 12, 2015·Nature Reviews. Endocrinology·Emanuel E CanforaEllen E Blaak
Nov 5, 2014·Journal of the Science of Food and Agriculture·Ganapathi Raj Murugesan, Michael E Persia
Feb 8, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsien-Tsung YaoMeng-Tsan Chiang
Apr 18, 2015·European Journal of Microbiology & Immunology·E E FröhlichP Holzer

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