Effect of propionyl-l-carnitine and enalapril on cardiac function of pressure-overloaded rats during increase in load

European Journal of Pharmacology
R MichelettiG Bianchi

Abstract

Chronic administration of propionyl-l-carnitine has been recently shown to correct hypertrophy related abnormalities in muscle mechanics. Accordingly, this study investigated whether the drug would similarly improve cardiac dynamics in rats with pressure overload. Enalapril was used for comparison. Drugs were administered in the drinking water for 3 weeks to Wistar Kyoto rats with a 2 week abdominal aortic constriction. Cardiac function was studied under urethane anaesthesia in basal conditions, during increase in preload, and during increase in afterload. Basal cardiac function was comparable in pressure-overloaded and sham-operated animals. Neither propionyl-l-carnitine nor enalapril affected the basal performance. Compared to sham-operated animals, untreated pressure-overloaded rats showed an impaired cardiac response (cardiac output, stroke volume) to preload increase induced by saline i.v. infusion. Propionyl-l-carnitine dose dependently improved cardiac function in the range 30-180 mg/kg, without affecting cardiac hypertrophic growth. Enalapril (3 mg/kg) reduced cardiac hypertrophy and improved cardiac function. The two effects were unrelated. The afterload increase by total aortic occlusion evidenced a reduction in the l...Continue Reading

References

Feb 1, 1991·Cardiovascular Drugs and Therapy·N SiliprandiR Menabò
Dec 1, 1987·Journal of Cardiovascular Pharmacology·C S SweetL G Ribeiro
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Citations

Oct 23, 1997·Journal of Cardiac Failure·R Ferrari, F De Giuli

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