PMID: 16518521Mar 7, 2006Paper

Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication

Angiology
Antonio SilvestroMassimo Chiariello

Abstract

In patients with intermittent claudication, treadmill exercise may cause acute deterioration of endothelial function and increase in plasma concentrations of adhesion molecules. The authors evaluated the efficacy of intravenously administered propionylcarnitine (PLC)in preventing these phenomena. Thirty-six claudicants with postexercise decrease in brachial artery flow-mediated dilation (FMD)were randomized to either placebo or PLC (600 mg as a single bolus followed by 1 mg/kg/min for 60 minutes).In the 18 patients randomized to placebo, FMD markedly decreased with exercise before (from 6.8 +/-0.4% to 4.0 +/-0.4%; p < 0.001) and after treatment (from 6.5 +/-0.4% to 4.4 +/-0.5%; p < 0.001). By contrast, in the PLC group, FMD significantly decreased with exercise before treatment (from 8.0 +/-0.7% to 4.4 +/-0.4%; p < 0.001), but not after active drug administration (from 7.1 +/-0.7% to 6.0 +/-0.6%; p = 0.067). The difference between treatments was not significant (p = 0.099; ANOVA). However, in the PLC group, the authors found that the greater the exercise-induced deterioration in endothelial function before treatment, the greater the capacity of PLC to prevent a postexercise decrease in FMD (r = -0.50, p = 0.034). Accordingly, t...Continue Reading

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Citations

Nov 28, 2007·Cardiovascular Ultrasound·Jaume PadillaJanet P Wallace
Apr 14, 2010·Medicine and Science in Sports and Exercise·Emeline AufradetCyril Martin
Apr 15, 2011·Vascular Health and Risk Management·Carmen MingoranceMaría Dolores Herrera
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Mar 29, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hadi TabibiTahereh Malakoutian
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Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Natan D da SilvaEdilamar M de Oliveira
Dec 23, 2017·European Journal of Applied Physiology·Marko StupinInes Drenjancevic

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