Effect of propranolol and phenothiazines on electrodermal orienting and habituation in schizophrenia

Psychological Medicine
J H GruzelierN Yorkston

Abstract

Bilateral electrodermal orienting responses were measured to repeated auditory stimuli in schizophrenic patients and controls. In 3 studies phasic activity to moderate intensity sounds of patients on no drugs or phenothiazines was predominantly hyper- or hypo-responsive. Controls showed moderate or slow habituation. Propranolol was found to facilitate habituation in slow habituators and to reinstate responses in half of non-responders, especially when given as the sole drug. The effects seldom had a counterpart in changes in non-specific responses or levels of skin conductance. Modulatory influences on stimulus and response processing and on lateral asymmetries in responses may underlie propranolol's efficacy in treating schizophrenia.

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Citations

Jan 1, 1985·Journal of Psychosomatic Research·J H Gruzelier, T D Brow
Feb 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J Gruzelier, A Raine
May 24, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·John H Gruzelier
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Nov 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·J Gruzelier, R Manchanda
May 10, 2005·Acta Psychiatrica Scandinavica·M Dragovic, G Hammond

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