Sep 1, 1975

Effect of propranolol on antinociceptive and withdrawal characteristics of morphine

Pharmacology, Biochemistry, and Behavior
R E ChipkinW Lowenthal

Abstract

Propranolol at a dose (10 mg/kg) which did not alter tail-flick latency by itself, did not alter the ED50 of morphine when given 10 min prior to the narcotic. Propranolol at doses of 10 and 25 mg/kg given 10 min prior to naloxone challenge did not significantly alter the frequency of naloxone induced jumping 72 hr after morphine pellet implantation. The ED50 of naloxone in morphine pelleted mice was not altered by treatment with propranolol at 0, 24, and 48 hr after pellet implantation. Naloxone caused hyperactivity in mice when administered 72 hr after morphine pellet implantation. An injection of 25 mg/kg propranolol 10 min prior to naloxone did not block this hyperactivity. In addition, administration of 10 mg/kg of propranolol every 8 hr to rats during withdrawal from morphine failed to alleviate the withdrawal syndrome as evidenced by changes in either body weight or water intake. These data suggest that the beta-adrenergic blocking agent, propranolol, does not alter the antinociceptive activity or lessen the withdrawal syndrome of morphine in rodents.

Mentioned in this Paper

Reaction Time
Pellet Formation
Morphine Abuse
Naloxone
Morphine Measurement
Narcotics
Withdrawal Symptoms
Weighing Patient
Blastocyst Implantation, Natural
Propranolol

About this Paper

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