PMID: 2104945Jan 1, 1990Paper

Effect of propranolol on nitrogen and energy metabolism in sepsis

The Journal of Surgical Research
R N DickersonG P Buzby

Abstract

Pharmacologic therapy designed to block adrenergic activity or alter hormonal milieu may modulate energy and protein metabolism in stress. The metabolic effects of propranolol (beta adrenergic receptor blocker) in sepsis was investigated in 22 well-nourished rats that underwent superior vena caval cannulation, cecal ligation, and puncture. Animals were randomly assigned to receive either a continuous infusion of 0.7 mg/day of propranolol combined with parenteral nutrition (n = 11) or parenteral nutrition alone (n = 11). Both groups received isocaloric, isonitrogenous, isovolemic, parenteral nutrition post-operatively for 24 hr. Nitrogen balance was better for the propranolol group than for the control group (+743 +/- 84 mg/kg/day versus +300 +/- 63 mg/kg/day, respectively, P less than 0.05). A significant difference between the pharmacologic therapy and control groups was noted for urinary 3-methylhistidine excretion versus control (0.99 +/- 0.08 micrograms/kg/day versus 7.5 +/- 0.37 micrograms/kg/day, respectively, P less than 0.01). Measured energy expenditure was similar for both pharmacologic therapy and control groups (149 +/- 20 kcal/kg/day versus 134 +/- 11 kcal/kg/day, respectively, P = N.S.). No statistically significa...Continue Reading

References

Nov 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·C L LongW S Blakemore
Jan 1, 1975·Metabolism: Clinical and Experimental·L P GeorgesJ J Canary
Feb 1, 1986·Archives of Surgery·R C FriedG P Buzby
Aug 13, 1987·The New England Journal of Medicine·R R WolfeM Wolfe
May 1, 1985·The Journal of Surgical Research·P M BaileyG P Buzby
Feb 1, 1983·Resuscitation·G PelosiC Manni
Sep 1, 1984·Annals of Surgery·P Q BesseyD W Wilmore
Jan 1, 1980·Critical Care Medicine·D H Elwyn
Jan 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·A FLECK, H N MUNRO

❮ Previous
Next ❯

Citations

Oct 30, 2009·Critical Care : the Official Journal of the Critical Care Forum·Etienne de MontmollinDjillali Annane
Sep 12, 2002·Pharmacotherapy·Roland N Dickerson, Scott L Charland
Jul 19, 2008·Shock·Nathan M NovotnyDaniel R Meldrum
Mar 9, 2017·Journal of Intensive Care·Takeshi SuzukiHiroshi Morisaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.