PMID: 6405421Jan 1, 1983Paper

Effect of propranolol treatment in pregnant rats on motor activity and avoidance learning of the offspring

Psychopharmacology
Z SpeiserS Gitter

Abstract

Rats born to mothers treated with propranolol, during days 8-22 of gestation, displayed hyperactivity in the open field which lasted up to 60 days of age and an impairment of avoidance in the shuttle box which was more marked in the male rats. Females exhibited hyperactivity in the open field but developed impaired avoidance learning only when exposed prenatally to both propranolol and hypoxia. Propranolol administration during the last term of pregnancy (days 18-22) affected mostly shuttle box performance. In contrast, hyperactivity could be induced by treatment during various stages of pregnancy, (days 8-22, 8-18, or 18-22) with the duration of hyperactivity being directly related to the length of treatment of the mothers. The possible mechanism of the disruptive effect of propranolol in the fetus and newborn is discussed.

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Citations

Mar 5, 1993·Journal of Chromatography·M H BotterblomE B Erdtsieck-Ernste
Mar 29, 2001·Journal of Pharmaceutical and Biomedical Analysis·G MasciV Crescenzi
Oct 18, 2015·Neurotoxicology and Teratology·William R MundyJohn Cowden

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