PMID: 2105280Jan 1, 1990Paper

Effect of prostacyclin on coronary occlusion in acute myocardial infarction

International Journal of Cardiology
D HackettA Maseri

Abstract

Prostacyclin is a powerful inhibitor of platelet aggregation and induces relaxation of vascular smooth muscle. We have studied the coronary effects of high local concentrations of prostacyclin in 17 patients during the early stages of acute myocardial infarction. We infused graded concentrations of intracoronary prostacyclin and compared the effects to those of intracoronary isosorbide dinitrate before and after an intracoronary infusion of streptokinase. Considerable dilation of the infarct-related stenosis may follow local infusions of prostacyclin in some patients. In general, however, dilation of the infarct-related stenosis or coronary recanalization did not result from infusion of prostacyclin.

References

Jun 1, 1978·Pharmacological Research Communications·A SzczeklikJ Mruk
Jan 1, 1988·European Heart Journal·D HackettA Maseri
Dec 1, 1986·The American Journal of Cardiology·B SharmaJ A Franciosa
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Apr 25, 1981·Lancet·R J Hall, H A Dewar
May 1, 1983·British Heart Journal·J R Vane
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.