Effect of prostaglandin duration on outcomes in transposition of the great arteries with intact ventricular septum.

Congenital Heart Disease
Ryan J ButtsAndrew M Atz

Abstract

To study the effects of duration of preoperative prostaglandin E1 (PGE) exposure on perioperative outcomes of the arterial switch operation in patients with transposition of the great arteries with an intact ventricular septum. Retrospective chart review. Pediatric cardiac intensive care unit in a tertiary care children's hospital. All patients with transposition of the great arteries with an intact ventricular septum from 1995 to 2008. Inotropic score was calculated for all patients in the first 5 postoperative days and maximum inotropic score was recorded. Length of postoperative mechanical ventilation, fluid balance, mechanical ventilation time, as well as intensive care unit and hospital stay were recorded for all patients. Study population included 59 patients, 41 (69%) underwent balloon atrial septostomy. PGE was used in 52 patients, median exposure of 59 hours, range 0 to 272 hours. Longer preoperative PGE exposure was associated with longer preoperative mechanical ventilation (P < .001). There was no association between preoperative PGE duration and cardiopulmonary bypass time, cross-clamp time, or total hospital stay. Patients with longer preoperative PGE exposure had a lower postoperative inotrope score (10 vs. 15 P =...Continue Reading

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Citations

Aug 2, 2014·Journal of the American College of Cardiology·Juan VillafañeUNKNOWN American College of Cardiology’s Adult Congenital and Pediatric Cardiology Council
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Gil Wernovsky
Sep 21, 2016·Chinese Medical Journal·Qing-Yu WuMing-Kui Zhang
Apr 23, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Matthew D Files, Bhawna Arya

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