PMID: 9167210Apr 1, 1997Paper

Effect of prostaglandin E1 infusion in severe chronic heart failure

Prostaglandins
R PacherH Sinzinger

Abstract

Prostaglandin E1 (PGE1, alprostadil) is a potent vasodilating agent that is frequently used to resolve cardiogenic pulmonary hypertension. To investigate the effect of PGE1 in refractory chronic heart failure in a double-blind trial, twenty patients (17 men, 3 women, 58 +/- 2 years, cardiac index < or = 2.5 l/min/m2, pulmonary capillary wedge pressure > or = 20 mmHg), who were in NYHA functional class IV on optimized treatment with ACE inhibitors and furosemide were infused with 30 ng/kg/min PGE1 or placebo through 48 hours. All patients received a concomitant therapy with standardized catecholamine infusions which were given 24 hours in advance and were continued throughout the study. There was no difference in baseline values between the randomized groups before PGE1 or placebo was added. PGE1 resulted in decrements in pulmonary artery pressure (from 37 +/- 4 to 30 +/- 4 mmHg; p < 0.01), pulmonary capillary wedge pressure (from 26 +/- 4 to 19 +/- 3 mmHg p < 0.001) systemic vascular resistance index (from 2048 +/- 213 to 1506 +/- 13 dyn.sec/cm5.m2, p < 0.05) and in increments in cardiac index and stroke volume index (from 2.2 +/- 0.1 to 2.8 +/- 0.2 l/min.m2; p < 0.05 and from 23 +/- 2 to 28 +/- 2 l/m2; p < 0.05, respectively)....Continue Reading

References

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Citations

Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Branislav RadovancevicO H Frazier
Feb 19, 2000·Prostaglandins & Other Lipid Mediators·S C TrompM G oude Egbrink
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M R MehrabiH D Glogar
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeanette Strametz-JuranekBrigitte Stanek
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B StanekR Pacher
Aug 2, 2000·Critical Care Medicine·R G Johnson
Jul 28, 2011·Congestive Heart Failure·Andreas P KalogeropoulosVasiliki V Georgiopoulou

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