Effect of prostaglandin E1 on neuromuscular transmission in the rat

British Journal of Pharmacology
J GripenbergE M Tolppanen

Abstract

1 The effect of prostaglandin E1 on neuromuscular transmission in the phrenic nerve-diaphragm muscle preparation of the rat was studied with intra- and extracellular recording techniques. 2 Prostaglandin E1, in concentrations from 10 nM, induced intermittent failures in the generation of the end-plate potential in response to repeated indirect stimulation. 3 Failures appeared abruptly, the end-plate potential behaving in an all-or-nothing fashion. The effect occurred only at 36-38 degrees C when the nerve was stimulated at 30-80 Hz and was reversible upon washing with drug-free solution. 4 Since miniature end-plate potentials were not affected, such failures must be attributed to a presynaptic action of prostaglandin E1. 5 Extracellular recording suggested that prostaglandin E1 prevented the action potential from reaching the nerve terminal.

References

Nov 23, 1973·Brain Research·A Dahlström
Dec 1, 1968·The Journal of Physiology·B Katz, R Miledi
May 1, 1970·Acta Physiologica Scandinavica·P HedqvistA Wennmalm
Apr 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·A Wennmalm, P Hedqvist
May 1, 1971·British Journal of Pharmacology·B L Ginsborg, G D Hirst
Nov 1, 1972·Journal of the Neurological Sciences·K Lowitzsch, H C Hopf
Sep 1, 1973·European Journal of Pharmacology·P HadházyJ Knoll
Sep 1, 1973·Canadian Journal of Physiology and Pharmacology·L A Marco, F Coceani
Nov 1, 1969·British Journal of Pharmacology·J L Laity
May 1, 1966·The Journal of Physiology·R Miledi, C R Slater
Oct 1, 1967·The American Journal of Physiology·F CoceaniL S Wolfe
May 1, 1962·The Journal of Physiology·J C ECCLESW D WILLIS
Dec 15, 1962·Experientia·J A BARSTAD
Sep 1, 1964·The Journal of Physiology·M RANDIC, D W STRAUGHAN
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI
Dec 1, 1959·The Journal of Physiology·K KRNJEVIC, R MILEDI
Nov 4, 1960·Science·M L WolbarshtH G Wagner

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