Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Alex Y HuiJoseph J Y Sung

Abstract

Hepatic stellate cells (HSC) are central to liver fibrosis. The eicosanoid pathway and cyclooxygenase-2 (COX-2) may be an important signaling mechanism in HSC. We investigated the role of COX-2, prostaglandin E(2) (PGE(2)) and prostaglandin I(2) (PGI(2)) in proliferation of LI90, an immortalized cell line of HSC. Our results showed that COX-2 was upregulated by platelet-derived growth factor (PDGF), a mitogen in HSC. COX-2 was responsible for the production of PGE(2) and PGI(2) in PDGF-stimulated LI90 cells. Furthermore, we demonstrated that COX-2 and PGE(2) mediated the proliferative response of LI90 to PDGF while synthetic analogue of PGI(2) exhibited anti-proliferative effect. Our findings suggest complex interactions of prostaglandins in liver fibrogenesis. In vivo studies using animal models are needed to elucidate the effect of COX-2 inhibition by non-steroidal anti-inflammatory drugs or COX-2 inhibitor in hepatic fibrosis.

References

Mar 1, 1986·Gastroenterology·F GuarnerJ Balanzo
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F ObertiD Lebrec
Dec 27, 1996·The Journal of Biological Chemistry·W L SmithD L DeWitt
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F MarraP Gentilini
Aug 10, 1999·Journal of Gastroenterology and Hepatology·D Li, S L Friedman
Nov 2, 1999·Biochemical and Biophysical Research Communications·D J Wadleigh, H R Herschman
Jun 20, 2001·The Journal of Clinical Investigation·W L Smith, R Langenbach
Jul 4, 2001·The Journal of Clinical Investigation·C PatronoL A García Rodríguez
Sep 12, 2001·The Journal of Biological Chemistry·T HataeT Tanabe
Oct 5, 2001·Seminars in Liver Disease·M Pinzani, F Marra
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Helen L Reeves, Scott L Friedman
Mar 13, 2003·World Journal of Gastroenterology : WJG·Xiao-Zhong WangBin Li
Oct 29, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ke-Qin Hu

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Citations

May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Areeba Ahmad, Riaz Ahmad
Jun 9, 2007·Expert Opinion on Biological Therapy·Enrico Maria ZardiAntonella Afeltra
Feb 9, 2016·Canadian Journal of Physiology and Pharmacology·Yan YangJun Li
Jan 29, 2009·Gastroenterología y hepatología·Juan ClàriaNatàlia Ferré
Jan 20, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Alex Yui HuiJoseph Jao Yiu Sung
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Jens HerrmannRalf Weiskirchen
Oct 22, 2008·Journal of Cellular Physiology·Chih-Chiang ChienYen-Chou Chen
Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Liena ZhaoZu-hua Gao
Dec 13, 2005·Cancer Treatment Reviews·Tong Wu
Sep 20, 2005·Experimental Cell Research·Jeffrey S OtisGrace K Pavlath
May 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brenda A BondesenGrace K Pavlath
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Momoka YamaguchiTomohisa Ishikawa

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