Effect of prostaglandin E2 on acetylcholine release from some peripheral cholinergic nerve terminals

European Journal of Pharmacology
M Das, D K Ganguly

Abstract

The effect of prostaglandin E2 (PGE2) on the acetylcholine (ACh) release evoked from rat phrenic nerve terminals and from Auerbach's plexus of the guinea-pig ileum was investigated. PGE2 enhanced the evoked release of ACh from phrenic nerve terminals and from Auerbach's plexus in a concentration-dependent manner. Preincubation with 7-oxa-13-prostynoic acid, the PGE receptor blocker, and indomethacin inhibited the PGE2-induced increase of evoked release of ACh while atropine failed to do so. Whereas a single administration of either 7-oxa-13-prostynoic acid or indomethacin significantly inhibited the control evoked release of ACh from the Auerbach's plexus, they failed to alter the control evoked release of ACh from the phrenic nerve terminals. The study indicates that the PGE2-induced increase in release of ACh from cholinergic nerve terminals is accomplished through activation of prostaglandin receptors and that PGE2 may play a physiological role in ACh liberation from the cholinergic autonomic nerve terminals but not from motor nerve terminals.

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Citations

Feb 1, 1989·Digestive Diseases and Sciences·O LundgrenL Jivegård
Dec 21, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E MochikiZ Itoh
May 25, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E FairbrotherH M Cox
Aug 28, 2002·The Journal of Pharmacy and Pharmacology·Paolo TucciPaola Bolle
May 1, 1988·Clinical and Experimental Pharmacology & Physiology·M L Go, H S Lee
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Serio, E E Daniel
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FitzgeraldD L Kaminski
Apr 8, 1998·The American Journal of Physiology·L J Jennings, G M Mawe
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian P ManningGary M Mawe
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S I Myers

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