Effect of prostaglandin E2 on gastric mucosal bleeding caused by aspirin

Digestive Diseases and Sciences
J N Hunt, D R Franz

Abstract

The effect of prostaglandin E2 on gastric mucosal bleeding caused by aspirin was studied. Blood in serial gastric washings was measured chemically for 30 min. Normal blood loss was equivalent to 0.05 ml/day. Aspirin, 600 mg four times daily, increased gastric bleeding on day 1; bleeding was further increased on day 2. On day 2, ingestion of 0.5 mg of prostaglandin E2 15 min before 600 mg of aspirin reduced the gastric microbleeding caused by aspirin. Prostaglandin E2, 0.5 mg four times daily, did not change the normal blood loss. No consistent changes in gastric emptying or in secretion of chloride were detected.

References

Jan 1, 1976·Digestion·M A Fisher, J N Hunt
Dec 9, 1978·Lancet·M M Cohen
Jun 1, 1979·European Journal of Clinical Investigation·C Johansson, B Kollberg
Jul 1, 1979·Digestive Diseases and Sciences·J N Hunt
Oct 15, 1971·Nature·C D Darlington
Apr 15, 1950·The Journal of Physiology·R B Fisher, J N Hunt

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Citations

May 1, 1984·Digestive Diseases and Sciences·S B Reele, D Bohan
Jul 1, 1985·Digestive Diseases and Sciences·M M CohenJ D'Souza
Feb 1, 1983·Digestive Diseases and Sciences·J N HuntC L Jiang
Oct 1, 1983·Digestive Diseases and Sciences·J N HuntL Kessler
Jan 1, 1986·Postgraduate Medical Journal·K W Somerville, C J Hawkey
Nov 1, 1989·British Journal of Clinical Pharmacology·G K KitchingmanC J Hawkey
Nov 1, 1985·Journal of Clinical Pharmacology·N CharletR J Wills
Aug 1, 1989·Baillière's Clinical Rheumatology·E L Semble, W C Wu
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·M CucalaA L Blum
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·C JohanssonA Uribe
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·C Johansson
Jun 1, 1985·Scandinavian Journal of Gastroenterology·S J Konturek
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·A Aly
Oct 1, 1989·Alimentary Pharmacology & Therapeutics·I W FellowsC J Hawkey
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·C J HawkeyK W Somerville
Jun 1, 1988·Alimentary Pharmacology & Therapeutics·C J HawkeyS Marshall
Dec 1, 1987·Alimentary Pharmacology & Therapeutics·C J Hawkey
Sep 1, 1989·Scandinavian Journal of Gastroenterology·G ThiefinP Zeitoun
Dec 1, 1989·Alimentary Pharmacology & Therapeutics·K BerstadA Berstad
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·M M Cohen
May 1, 1987·Seminars in Arthritis and Rheumatism·E L Semble, W C Wu

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