Effect of protein adsorption on the radial wicking of blood droplets in paper

Journal of Colloid and Interface Science
Michael J HertaegGil Garnier

Abstract

(1) The equilibrium size and characteristics of a radially wicked fluid on porous material such as paper is expected to be dependent on the fluid properties and therefore could serve as a diagnostic tool. (2) The change in wicked stain size between biological fluids is dependent on a change in solid-liquid surface interfacial energy due to protein adsorption. Sessile droplets of increasing volume of blood, its components, and model fluids were deposited onto paper and the equilibrium stain size after coming to a halt was recorded. The contact angle of fluid droplets on model cellulose surfaces was measured to quantify the effect that blood protein adsorption at the solid-liquid interface has on radially wicked equilibrium size. Finally the significance of droplet evaporation for the time scale of interest was analysed. The final stain area of all fluids tested on paper scales remarkably linearly with droplet volume. Different fluids were compared and the gradient of this linear relation was measured. Model fluids varying in surface tension and viscosity all behave similarly and exhibit a constant gradient. Blood and its components produce smaller stains, demonstrated by lower gradients. The gradient is a function of protein con...Continue Reading

Citations

Jul 12, 2019·The Analyst·Marek BialkowerGil Garnier
Dec 17, 2020·The Analyst·Michael J HertaegGil Garnier
Dec 29, 2020·Journal of Colloid and Interface Science·Christine BrowneWarren Batchelor
Feb 12, 2020·Analytica Chimica Acta·Marek BialkowerGil Garnier
Jun 22, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Michael J HertaegGil Garnier
Jun 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Michael J HertaegGil Garnier

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