Mar 1, 1983

Effect of protein binding on antibiotic activity in vivo

The Journal of Antimicrobial Chemotherapy
D J MerrikinG N Rolinson

Abstract

Using a group of penicillins all belonging to the same chemical class, antibacterial activity against Staphylococcus aureus was determined in vitro and also in vivo by use of an intraperitoneal infection in mice. The compounds all showed essentially the same level of activity in vitro but differed markedly in their activity in vivo. This activity in vivo could be correlated directly with the extent of binding in mouse serum.

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Mentioned in this Paper

In Vivo
Protein Binding
Bacteriocidal Agents
Serum Proteins
Staphylococcal Infections
Plasma Protein Binding Capacity
Bactericidal Activity
Binding (Molecular Function)
Intraperitoneal
Staphylococcus aureus

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