Effect of protein on sympathetic nervous system activity in the rat. Evidence for nutrient-specific responses

The Journal of Clinical Investigation
L N KaufmanL Landsberg

Abstract

Increased energy intake activates the sympathetic nervous system (SNS) in animals and man. While dietary carbohydrate and fat stimulate, the impact of dietary protein on the SNS is not well defined. The present studies examine the effect of protein ingestion on sympathetic function based upon the measurement of [3H]norepinephrine (NE) turnover in heart and interscapular brown adipose tissue (IBAT) as the index of SNS activity. In these experiments, animals were pair-fed mixtures of laboratory chow and refined preparations of casein, sucrose, and lard to permit comparisons among nutrients with total energy intake held constant or with additional energy provided in the form of a single nutrient. After 5 d of eating a 2:1 mixture of chow and either casein or sucrose cardiac, [3H]NE turnover was less (P less than 0.005) in casein-fed rats (6.4%/h and 28.9 ng NE/h) than in animals given sucrose (11.2%/h and 46.5 ng NE/h). Similar results were obtained in IBAT and in experiments using 1:1 mixtures of chow and casein/sucrose. Casein-fed animals also displayed slower rates of NE turnover than lard-fed rats in both heart (7.8%/h vs. 13.2, P less than 0.001) and IBAT (7.0%/h vs. 12.8, P less than 0.01). Addition of casein (50% increase i...Continue Reading

References

Apr 1, 1982·Scientific American·R J Wurtman
Jan 1, 1984·Metabolism: Clinical and Experimental·J G Vander Tuig, D R Romsos
May 1, 1983·The Journal of Clinical Investigation·T S JohnsonL Landsberg
Jul 1, 1983·The Journal of Clinical Investigation·J H SchwartzL Landsberg
May 1, 1982·The Journal of Clinical Investigation·J B YoungL Landsberg

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Citations

Dec 1, 1995·Diabetes/metabolism Reviews·B Capaldo, L Saccà
Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·E PelesM Modan
May 18, 2006·Cellular and Molecular Neurobiology·Lewis Landsberg
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Sep 1, 1990·Journal of Neuroscience Methods·L Landsberg
Jul 22, 1998·Journal of the Autonomic Nervous System·M N BritoR H Migliorini
Aug 23, 2006·Clinical and Experimental Pharmacology & Physiology·Lewis Landsberg
Jul 1, 1997·Acta Paediatrica. Supplement·A de KlerkM Myers
Jun 8, 2000·Annals of the New York Academy of Sciences·L Landsberg
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Dec 2, 2014·Obesity Research & Clinical Practice·Tomoya SakamotoTeruo Kawada
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·L Landsberg
Aug 12, 2008·European Urology·Nancy Nairi MaserejianJohn B McKinlay
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L Landsberg
Feb 1, 1994·Metabolism: Clinical and Experimental·J KolanowskiL Landsberg
Sep 13, 2005·Metabolism: Clinical and Experimental·Paul ValensiJean-Raymond Attali
Feb 4, 1998·Obesity Research·D NagyS B Heymsfield
May 29, 2007·American Journal of Hypertension·Raphael R de A FreitasMiriam S Dolnikoff
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Jul 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·N N'Guyen ThiP Valensi
Jan 12, 2019·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Mar 1, 1991·The American Journal of Physiology·N K FukagawaJ B Young

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