Effect of protein overfeeding on energy expenditure measured in a metabolic chamber

The American Journal of Clinical Nutrition
George A BraySteven R Smith

Abstract

Energy expenditure (EE) increases with overfeeding, but it is unclear how rapidly this is related to changes in body composition, increased body weight, or diet. The objective was to quantify the effects of excess energy from fat or protein on energy expenditure of men and women living in a metabolic chamber. We conducted a randomized controlled trial in 25 participants who ate ∼40% excess energy for 56 d from 5%, 15%, or 25% protein diets. Twenty-four-hour EE (24EE) and sleeping EE (SleepEE) were measured on days 1, 14, and 56 of overfeeding and on day 57 while consuming the baseline diet (usually day 57). Metabolic and molecular markers of muscle metabolism were measured in skeletal muscle biopsy specimens. In the low-protein diet group whose excess energy was fat, the 24EE and SleepEE did not increase during the first day of overfeeding. When extra energy contained protein, both 24EE and SleepEE increased in relation to protein intake (r = 0.50, P = 0.02). The 24EE over 8 wk in all 3 groups was correlated with protein intake (r = 0.60, P = 0.004) but not energy intake (r = 0.16; P = 0.70). SleepEE was unchanged by overfeeding in the low-protein diet group, and baseline surface area predicted increased 24EE in this group. Pro...Continue Reading

References

Jul 1, 1975·The Journal of Nutrition·D H Calloway
Oct 1, 1992·The American Journal of Clinical Nutrition·E O DiazW A Coward
Jun 1, 1992·The American Journal of Clinical Nutrition·C BennettJ O Hill
Jan 1, 1987·Annual Review of Nutrition·E JéquierY Schutz
Jan 1, 1985·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J RafaelG Heldmaier
Sep 1, 1985·The Journal of Clinical Investigation·J P FlattE Jéquier
Dec 1, 1971·The American Journal of Clinical Nutrition·M ApfelbaumD Lacatis
Jan 1, 1967·Scandinavian Journal of Clinical and Laboratory Investigation·J Bergström, E Hultman
Mar 1, 1984·The British Journal of Nutrition·G E Butterfield, D H Calloway
Jul 1, 1984·The British Journal of Nutrition·H M Dallosso, W P James
Jul 1, 1995·The American Journal of Clinical Nutrition·T J HortonJ O Hill
Nov 7, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R J StubbsC Reid
Dec 1, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M J Stock
Jan 29, 2000·The American Journal of Clinical Nutrition·S R SmithG A Bray
Jun 29, 2000·The American Journal of Clinical Nutrition·S R SmithG A Bray
Aug 2, 2000·The American Journal of Clinical Nutrition·R M McDevittA M Prentice
Nov 1, 1954·The American Journal of Clinical Nutrition·D H CALLOWAY, H SPECTOR
Oct 7, 2004·Journal of the American College of Nutrition·Thomas L Halton, Frank B Hu
Jul 26, 2005·Physiology & Behavior·Annemiek M C P JoosenKlaas R Westerterp
Nov 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Mario SiervoSusan A Jebb
Jan 30, 2009·The American Journal of Clinical Nutrition·Ananda Hochstenbach-WaelenKlaas R Westerterp
Apr 30, 2009·Annual Review of Nutrition·M S Westerterp-PlantengaK R Westerterp
Dec 14, 2011·The Journal of Clinical Endocrinology and Metabolism·M AlligierM Laville
Jan 5, 2012·JAMA : the Journal of the American Medical Association·George A BrayLeanne M Redman
Aug 7, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S B HeymsfieldM J Müller
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A G DullooY Schutz
Dec 13, 2012·European Journal of Clinical Nutrition·K R Westerterp
Jan 4, 2013·The Journal of Clinical Endocrinology and Metabolism·Maud AlligierMartine Laville
Mar 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Charmaine S TamEric Ravussin

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Citations

Oct 4, 2016·The Journal of Nutritional Biochemistry·Begoña Ruiz-NúñezFrits A J Muskiet
Nov 8, 2016·Molecular Metabolism·Yan Y Lam, Eric Ravussin
Oct 16, 2016·Current Obesity Reports·Manfred J MüllerAnja Bosy-Westphal
Sep 28, 2018·Diabetes·Karyne L VinalesPaolo Piaggi
Feb 13, 2018·Journal of the International Society of Sports Nutrition·Jose AntonioCorey A Peacock
Sep 2, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magdalena StepienClaire Gaudichon
Jan 12, 2020·Advances in Nutrition·George A Bray
May 10, 2016·The Journal of Clinical Endocrinology and Metabolism·George A BraySteven R Smith
Nov 7, 2019·Current Diabetes Reports·Manfred James Müller, Anja Bosy-Westphal
Aug 3, 2020·Reviews in Endocrine & Metabolic Disorders·Faidon Magkos
Jan 12, 2019·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Dec 3, 2016·European Journal of Clinical Nutrition·K R Westerterp
Jul 8, 2020·Nutrients·Jose AntonioJustin Roberts
Jun 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·George A Bray, Claude Bouchard
Nov 29, 2020·The American Journal of Clinical Nutrition·Camila L P OliveiraCarla M Prado
Dec 2, 2020·American Journal of Men's Health·A KarpikA Chwałczynska
Dec 29, 2020·International Journal of Sport Nutrition and Exercise Metabolism·Motoko TaguchiTakayuki Sako
Jun 17, 2021·The American Journal of Clinical Nutrition·Manfred J MüllerAnja Bosy-Westphal

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