Effect of proton pump inhibitors and H2 antagonists on the stomach wall in 99mTc-sestamibi cardiac imaging

Journal of Nuclear Medicine Technology
Sumina GoelE Gordon DePuey

Abstract

On the basis of previously unpublished observations, we hypothesized that prolonged use of proton pump inhibitors (PPIs) causes an increase in (99m)Tc-sestamibi uptake in the stomach wall, manifested as curvilinear activity surrounding the photopenic fundus of the stomach cavity. We prospectively evaluated the frequency of stomach wall uptake in patients undergoing myocardial perfusion SPECT who were taking PPIs or H(2) antagonists. Patients (n = 138) who were scheduled for single-day rest/stress (99m)Tc-sestamibi SPECT were randomly selected. Poststress SPECT was performed 30 min after treadmill exercise or 45 min after dipyridamole infusion. The rest scan was obtained 45 min after tracer injection. All patients drank 473 mL of water 5-10 min after both the rest and the stress radiotracer injections. Patients were questioned regarding their use of PPIs and H(2) antagonists. The significant use of either was defined as more than 2 wk of continuous therapy before cardiac SPECT. Masked observers assessed poststress planar projection images in endless-loop cinematic format for the following 3 patterns: stomach cavity uptake, attributable to duodenogastric reflux of tracer; stomach wall uptake; and no stomach uptake. A 2-tailed chi...Continue Reading

Citations

Sep 18, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Pradeep BhambhvaniAmi Iskandrian
Nov 12, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hadi MalekRaheleh Hedayati
Jul 17, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jacek KwiecinskiPiotr J Slomka
Jan 4, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stephen A Bloom, Randall C Thompson
May 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Harpreet SinghMadan Parmar
Jul 31, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mohsen Qutbi
Jun 30, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sean R McMahon, W Lane Duvall
Nov 7, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E Gordon DePuey
Nov 20, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·David S RoseJoseph C Lee
Nov 27, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Atif H AlzahraniBenjamin J W Chow
Feb 3, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ghazal NorouziElahe Pirayesh
May 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael AlJaroudi
Aug 6, 2016·Journal of Nuclear Medicine Technology·Grace BrayshawGeoff Currie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.