Effect of proton pump inhibitors on glycemic control in patients with diabetes

World Journal of Diabetes
Kohzo Takebayashi, Toshihiko Inukai

Abstract

Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal cells, gastrin can also behave as a growth factor and stimulate gastric cell proliferation. It is also reported that gastrin promotes β cell neogenesis in the pancreatic ductal complex, modest pancreatic β cell replication, and improvement of glucose tolerance in animal models, in which the remodeling of pancreatic tissues is promoted. These findings suggest the possibility that gastrin has the potential to promote an increase of β cell mass in pancreas, and therefore that gastrin may improve glucose tolerance. Proton pump inhibitors (PPIs) are wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. PPIs indirectly elevate serum gastrin levels via a negative feedback effect. Recent evidence has revealed the beneficial effect of PPIs on glycemic control especially in patients with type 2 diabetes mellitus (T2DM), probably via the elevation of the levels of serum gastrin, although the detailed mechanism remains unclear. In addition, the benef...Continue Reading

Citations

Feb 18, 2016·Expert Opinion on Investigational Drugs·André J Scheen
Feb 8, 2019·Metabolic Syndrome and Related Disorders·Kelly VillegasArthur Swislocki
Jun 8, 2017·The Journal of Clinical Endocrinology and Metabolism·Timothy M E DavisWendy A Davis
Jan 30, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Yusuf BozkuşNeslihan B Tütüncü
Jul 6, 2019·European Journal of Medicinal Chemistry·Florence LerouxRebecca Deprez-Poulain
Jun 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Carol Chiung-Hui PengKashif M Munir

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